N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide

Base Information

Chemical Name:N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide
CAS No.:61350-01-4
Molecular Formula:C13H9F3N2O
Molecular Weight:266.222
Hs Code.:
DSSTox Substance ID:DTXSID40367967
Nikkaji Number:J2.152.063B
Wikidata:Q82154195
ChEMBL ID:CHEMBL571453

Synonyms:N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide;CHEMBL571453;61350-01-4;N-(3-(trifluoromethyl)phenyl)picolinamide;Enamine_000218;cid_2306530;DTXSID40367967;QJUCVRVRFWBVTF-UHFFFAOYSA-N;HMS1394J20;BDBM50293719;AKOS001382124;VU0361739-1;EN300-26866773;Z28169793

Suppliers and Price of N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide

Chemical Property:

XLogP3:2.9
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:2
Exact Mass:266.06669740
Heavy Atom Count:19
Complexity:320

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CC=NC(=C1)C(=O)NC2=CC=CC(=C2)C(F)(F)F

Technology Process of N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide

There total 6 articles about N-[3-(trifluoromethyl)phenyl]pyridine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

: 98-98-6
2-Picolinic acid

: 98-16-8
3-trifluoromethylaniline

: 61350-01-4
N-[3-(trifluoromethyl)phenyl]-2-pyridinecarboxamide

Guidance literature:: 2-Picolinic acid; With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In 1,4-dioxane; at 20 ℃;

3-trifluoromethylaniline; In 1,4-dioxane; at 50 ℃;
DOI:10.1021/jm9005065

Reference yield: 61.0%

: 110-86-1
pyridine

: 3-trifluoromethylphenyl isonitrile

: 109-09-1
2-chloropyridine

: 61350-01-4
N-[3-(trifluoromethyl)phenyl]-2-pyridinecarboxamide

: 2-oxo-2-pyridin-2-yl-N-(3-trifluoromethyl-phenyl)-acetamide

Guidance literature:: pyridine; With fluorine; In dichloromethane; at -78 - -50 ℃;

3-trifluoromethylphenyl isonitrile; In dichloromethane; at -50 - 0 ℃; for 4h;
DOI:10.1016/j.tetlet.2005.02.010

Reference yield:

: 98-98-6
2-Picolinic acid

: 98-08-8
α,α,α-trifluorotoluene

: 61350-01-4
N-[3-(trifluoromethyl)phenyl]-2-pyridinecarboxamide

Guidance literature:: With benzotriazol-1-ol; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 20 ℃; for 12h;