Chloromethyl Dodecanoate

Base Information

• Chemical Name: Chloromethyl Dodecanoate
• CAS No.: 61413-67-0
• Molecular Formula: C13H25ClO2
• Molecular Weight: 248.793
• Mol file: 61413-67-0.mol

Synonyms:1-dodecanoyloxymethyl chloride;Dodecanoic acid,chloromethyl ester;chloromethyl n-dodecanoate;Chlormethyllaurat;Chloromethyl laurate;chloromethyldodecanoate;

Chemical Property of Chloromethyl Dodecanoate

Chemical Property:

• Boiling Point: 296.1±13.0 °C(Predicted)
• PSA: 26.30000
• Density: 0.964±0.06 g/cm3(Predicted)
• LogP: 4.64680

Purity/Quality:

99.5%, ^*data from raw suppliers

ChloromethylLaurate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Chloromethyl Laurate is used as a reagent in the synthesis of levofloxacin derivatives as potential antitumor agents. Also used as a reagent in the synthesis of prodrugs of Norbormide (N661150).

Technology Process of Chloromethyl Dodecanoate

There total 7 articles about Chloromethyl Dodecanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

lauric acid (143-07-7) + chlorosulfuric acid chloromethyl ester (49715-04-0) → chloromethyl n-dodecanoate (61413-67-0)

Guidance literature:

With sodium carbonate; tetra(n-butyl)ammonium hydrogensulfate; In dichloromethane; water; at 0 - 20 ℃; for 19h;

DOI:10.1016/j.bmc.2005.11.063

Reference yield: 84.0%

n-dodecanoyl chloride (112-16-3) + dichloromethane (75-09-2) → chloromethyl n-dodecanoate (61413-67-0)

Guidance literature:

n-dodecanoyl chloride; With zinc(II) chloride; at 0 - 70 ℃; for 24h; Inert atmosphere;

dichloromethane;

Reference yield: 71.0%

formaldehyd (50-00-0,30525-89-4,61233-19-0) + n-dodecanoyl chloride (112-16-3) → chloromethyl n-dodecanoate (61413-67-0)

Guidance literature:

With zinc(II) chloride; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1002/chem.201903976

upstream raw materials:

formaldehyd

n-dodecanoyl chloride

lauric acid

chlorosulfuric acid chloromethyl ester

Downstream raw materials:

dodecanoic acid [7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2-oxo-1(2H)-quinolinyl]methyl ester

1-<(dodecanyloxy)methyl>-3-methylimidazolium chloride

Refernces

• 1、 Gaillard, Boris,Seguin, Cendrine,Remy, Jean-Serge,Pons, Fran?oise,Lebeau, Luc. "Erufosine (ErPC3) Cationic Prodrugs as Dual Gene Delivery Reagents for Combined Antitumor Therapy". . p. 15662 - 15679. Retrieved 2019.
• 2、 -. "2, 4-dinitrophenol derivative and application thereof". Paragraph 0115-0116; 0118. . Retrieved 2020/08/18.
• 3、 -. "PRODRUGS OF A CDK INHIBITOR FOR TREATING CANCERS". Paragraph 00120. . Retrieved 2020/11/03.