1,3-Bis(4-methoxyphenyl)propan-1-one

Base Information

• Chemical Name: 1,3-Bis(4-methoxyphenyl)propan-1-one
• CAS No.: 20615-47-8
• Molecular Formula: C17H18O3
• Molecular Weight: 270.328
• Hs Code.: 2914509090
• NSC Number: 83182
• DSSTox Substance ID: DTXSID00292488
• Nikkaji Number: J743.183J
• Wikidata: Q82030811
• ChEMBL ID: CHEMBL1735986
• Mol file: 20615-47-8.mol

Synonyms:20615-47-8;1,3-bis(4-methoxyphenyl)propan-1-one;4'-METHOXY-3-(4-METHOXYPHENYL)PROPIOPHENONE;1,3-bis(4-methoxyphenyl)-1-propanone;4',4-Dimethoxydihydrochalcone;MFCD00757267;NSC83182;NCIOpen2_005125;MLS001180556;4?,4-Dimethoxydihydrochalcone;SCHEMBL7868896;CHEMBL1735986;DTXSID00292488;HMS2782F14;NSC 83182;NSC-83182;AKOS009347853;1,3-bis(4-methoxyphenyl)-propan-1-one;SMR000476559;XD161921;AK-087/42718365

Chemical Property of 1,3-Bis(4-methoxyphenyl)propan-1-one

Chemical Property:

• Vapor Pressure: 1.67E-07mmHg at 25°C
• Melting Point: 42-43 °C
• Boiling Point: 427.2°C at 760 mmHg
• Flash Point: 203.9°C
• PSA: 35.53000
• Density: 1.098g/cm³
• LogP: 3.51930
• XLogP3: 3.4
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 270.125594432
• Heavy Atom Count: 20
• Complexity: 287

Purity/Quality:

99% ^*data from raw suppliers

4'-Methoxy-3-(4-methoxyphenyl)propiophenone 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)CCC(=O)C2=CC=C(C=C2)OC

Technology Process of 1,3-Bis(4-methoxyphenyl)propan-1-one

There total 25 articles about 1,3-Bis(4-methoxyphenyl)propan-1-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

4,4'-dimethoxychalcone (2373-89-9) → 1,3-di(4-methoxyphenyl)propan-1-one (20615-47-8)

Guidance literature:

With borane-ammonia complex; In methanol; water; at 20 ℃; for 3h; chemoselective reaction;

DOI:10.1039/d0nj03104f

Reference yield: 95.0%

4-Methoxybenzyl alcohol (105-13-5) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 1,3-di(4-methoxyphenyl)propan-1-one (20615-47-8)

Guidance literature:

With potassium tert-butylate; C₃₅H₃₃Cl₂CoN₅O₂; In toluene; at 110 ℃; for 24h; Reagent/catalyst; Catalytic behavior; Inert atmosphere;

DOI:10.1039/d0dt03748f

Reference yield: 93.0%

1-(4-methoxyphenyl)cyclopropan-1-ol (15973-65-6) + 4-methoxyphenylboronic acid (5720-07-0) → 1,3-di(4-methoxyphenyl)propan-1-one (20615-47-8)

Guidance literature:

With copper diacetate; palladium diacetate; 1,2-bis-(diphenylphosphino)ethane; In water; dimethyl sulfoxide; at 70 ℃; for 2h; Solvent; Reagent/catalyst; chemoselective reaction;

DOI:10.1021/acs.joc.0c00160

upstream raw materials:

4,4'-dimethoxychalcone

(E)-1,3-bis(4-methoxyphenyl)-2-propene-1-one

4-Methoxybenzyl alcohol

1-(4-methoxyphenyl)ethanone

Downstream raw materials:

1,3-bis-(4-methoxy-phenyl)-propane-1,2-dione-2-oxime

2-Bromo-1,3-bis-(4-methoxy-phenyl)-propan-1-one

(E)-1-methoxy-4-(3-(4-methoxyphenyl)allyl)benzene

N,5-bis(4-methoxybenzyl)-4-(4-methoxyphenyl)thiazol-2-amine

Refernces

• 1、 Singh, Anshu,Maji, Ankur,Joshi, Mayank,Choudhury, Angshuman R.,Ghosh, Kaushik. "Designed pincer ligand supported Co(ii)-based catalysts for dehydrogenative activation of alcohols: Studies onN-alkylation of amines, α-alkylation of ketones and synthesis of quinolines". . p. 8567 - 8587. Retrieved 2021/06/30.
• 2、 Bayrak, Cetin,Menzek, Abdullah,Sevim, Melike. "Monodisperse NiPd alloy nanoparticles decorated on mesoporous graphitic carbon nitride as a catalyst for the highly efficient chemoselective reduction of α,β-unsaturated ketone compounds". . p. 13606 - 13612. Retrieved 2020/09/07.