Benzamide, N-(trimethylsilyl)-N-[2-[(trimethylsilyl)oxy]-4-pyrimidinyl]-

Base Information

• Chemical Name: Benzamide, N-(trimethylsilyl)-N-[2-[(trimethylsilyl)oxy]-4-pyrimidinyl]-
• CAS No.: 64339-87-3
• Molecular Formula: C17H25N3O2Si2
• Molecular Weight: 359.575
• DSSTox Substance ID: DTXSID30433963
• Nikkaji Number: J830.235I
• Wikidata: Q82248249

Synonyms:64339-87-3;Benzamide, N-(trimethylsilyl)-N-[2-[(trimethylsilyl)oxy]-4-pyrimidinyl]-;N-trimethylsilyl-N-(2-trimethylsilyloxypyrimidin-4-yl)benzamide;DTXSID30433963;N-(Trimethylsilyl)-N-[2-(trimethylsiloxy)pyrimidin-4-yl]benzamide

Chemical Property of Benzamide, N-(trimethylsilyl)-N-[2-[(trimethylsilyl)oxy]-4-pyrimidinyl]-

Chemical Property:

• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 359.14853012
• Heavy Atom Count: 24
• Complexity: 429

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C[Si](C)(C)N(C1=NC(=NC=C1)O[Si](C)(C)C)C(=O)C2=CC=CC=C2

Technology Process of Benzamide, N-(trimethylsilyl)-N-[2-[(trimethylsilyl)oxy]-4-pyrimidinyl]-

There total 9 articles about Benzamide, N-(trimethylsilyl)-N-[2-[(trimethylsilyl)oxy]-4-pyrimidinyl]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-N-benzoylcytosine (26661-13-2) + lithium hexamethyldisilazane (4039-32-1) → N4,O-bis(trimethylsilyl)-N4-benzoylcytosine (64339-87-3)

Guidance literature:

With ammonium sulfate; for 5h; Reflux;

DOI:10.1039/c5cc03617h

Reference yield:

4-N-benzoylcytosine (26661-13-2) + 1,1,1,3,3,3-hexamethyl-disilazane (999-97-3) → N4,O-bis(trimethylsilyl)-N4-benzoylcytosine (64339-87-3)

Guidance literature:

for 16h; Heating;

DOI:10.1055/s-1985-31214

Reference yield:

4-N-benzoylcytosine (26661-13-2) + N,O-Bis(trimethylsilyl)trifluoroacetamide (25561-30-2) → N4,O-bis(trimethylsilyl)-N4-benzoylcytosine (64339-87-3)

Guidance literature:

In acetonitrile; for 1h;

DOI:10.1021/jm049550o

upstream raw materials:

4-N-benzoylcytosine

1,1,1,3,3,3-hexamethyl-disilazane

Hexamethyldisiloxane

N,O-bis-(trimethylsilyl)-acetamide

Downstream raw materials:

4-Methyl-benzoic acid (3aR,4R,6aR)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

4-Methyl-benzoic acid (3aR,4R,6S,6aR)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

4-Methyl-benzoic acid (3aR,4R,6R,6aR)-6-(4-benzoylamino-2-oxo-2H-pyrimidin-1-yl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-ylmethyl ester

1-(5-acetoxy-5,6-dihydro-2H-pyran-2-yl)-4-benzoylamino-1H-pyrimidin-2-one

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