3-Butenoic acid, 2-hydroxy-4-phenyl-, ethyl ester, (2R,3E)-

Base Information

Chemical Name:3-Butenoic acid, 2-hydroxy-4-phenyl-, ethyl ester, (2R,3E)-
CAS No.:676477-93-3
Molecular Formula:C12H14O3
Molecular Weight:206.241
Hs Code.:

Synonyms:ethyl (E)-2-hydroxy-4-phenylbut-3-enoate;(R)-ethyl 2-hydroxy-4-phenylbut-3-enoate;

Suppliers and Price of 3-Butenoic acid, 2-hydroxy-4-phenyl-, ethyl ester, (2R,3E)-

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-Butenoic acid, 2-hydroxy-4-phenyl-, ethyl ester, (2R,3E)-

Chemical Property:

PSA：46.53000
LogP:1.62380

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

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Technology Process of 3-Butenoic acid, 2-hydroxy-4-phenyl-, ethyl ester, (2R,3E)-

There total 10 articles about 3-Butenoic acid, 2-hydroxy-4-phenyl-, ethyl ester, (2R,3E)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.8%

: 64-17-5
ethanol

: 117306-12-4,132617-10-8
(2R,3E)-2-hydroxy-4-phenyl-3-butenenitrile

: 676477-93-3
(2R)-(E)-2-Hydroxy-4-phenylbut-3-enoic acid ethyl ester

Guidance literature:: ethanol; (2R,3E)-2-hydroxy-4-phenyl-3-butenenitrile; for 0.166667h; Inert atmosphere; Cooling with ice;

With chloro-trimethyl-silane; at 4 ℃; for 20h; Inert atmosphere;
DOI:10.1021/acs.joc.6b02608

Reference yield: 64.0%

: 924-44-7
glyoxylic acid ethyl ester

: 19372-00-0
1-(trimethylsilyl)-2-phenylethene

: 676477-93-3
(2R)-(E)-2-Hydroxy-4-phenylbut-3-enoic acid ethyl ester

Guidance literature:: glyoxylic acid ethyl ester; 1-(trimethylsilyl)-2-phenylethene; With silver hexafluoroantimonate; [(R)-(+)-2,2'-bis(diphenylphosphino)-1,1'-binaphthyl]palladium(II) chloride; In dichloromethane; at 0 ℃; for 24h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; water; at 20 ℃; for 1h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/acs.orglett.7b00471

Reference yield:

: 64-17-5
ethanol

: 1914-59-6
(E)-2-oxo-4-phenyl-3-butenoic acid

: 125639-64-7
(S)-ethyl 2-hydroxy-4-phenylbutyrate

: 90315-82-5
ethyl (R)-2-hydroxy-4-phenylbutyrate

: 121155-45-1
(2S)-(E)-2-Hydroxy-4-phenylbut-3-enoic acid ethyl ester

: 676477-93-3
(2R)-(E)-2-Hydroxy-4-phenylbut-3-enoic acid ethyl ester

Guidance literature:: (E)-2-oxo-4-phenyl-3-butenoic acid; With hydrogenchloride; [RuCl(benzene){(2,2,2',2'-tetramethyl[4,4'-bibenzo[d][1,3]dioxole]-5,5'-diyl)bis(diphenylphosphine)}]Cl; water; hydrogen; In tetrahydrofuran; at 90 ℃; for 10h; under 20686.5 Torr; Autoclave;

ethanol; With sulfuric acid; for 5h; optical yield given as %ee; enantioselective reaction; Inert atmosphere; Reflux;
DOI:10.1021/jo101084t