ethyl 7-methoxyquinoline-3-carboxylate

Base Information

• Chemical Name: ethyl 7-methoxyquinoline-3-carboxylate
• CAS No.: 71082-46-7
• Molecular Formula: C₁₃H₁₃NO₃
• Molecular Weight: 231.251
• Hs Code.: 2933499090
• Mol file: 71082-46-7.mol

Synonyms:ethyl 7-methoxy-3-quinolinecarboxylate;3-ethoxycarbonyl-7-methoxyquinoline;

Chemical Property of ethyl 7-methoxyquinoline-3-carboxylate

Chemical Property:

• PSA: 48.42000
• LogP: 2.42010

Purity/Quality:

97% ^*data from raw suppliers

Ethyl7-Methoxyquinoline-3-carboxylate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Uses: Ethyl 7-Methoxyquinoline-3-carboxylate is a compound used in a study of rhodium-catalyzed ortho C-H bond activation of arylamines for the synthesis of quinoline carboxylates.

Technology Process of ethyl 7-methoxyquinoline-3-carboxylate

There total 7 articles about ethyl 7-methoxyquinoline-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

Ethyl 4-chloro-7-methoxyquinoline-3-carboxylate (77156-85-5) → ethyl 7-methoxy quinoline-3-carboxylate (71082-46-7)

Guidance literature:

With palladium 10% on activated carbon; palladium; In ethanol; ethyl acetate;

Reference yield: 81.0%

→ ethyl 7-methoxy quinoline-3-carboxylate (71082-46-7)

Guidance literature:

With dirhodium tetraacetate; In formic acid; at 25 ℃; Inert atmosphere;

Reference yield: 75.0%

formic acid (64-18-6) + m-Anisidine (536-90-3,918666-97-4) + propynoic acid ethyl ester (623-47-2) → 3-Methoxy-formanilid (27153-17-9) + ethyl 7-methoxy quinoline-3-carboxylate (71082-46-7)

Guidance literature:

With dirhodium tetraacetate; at 50 ℃; for 6h; Inert atmosphere;

DOI:10.1039/c6ob00170j

upstream raw materials:

Ethyl 4-chloro-7-methoxyquinoline-3-carboxylate

ethyl 4-hydroxy-7-methoxyquinoline-3-carboxylate

m-Anisidine

diethyl 2-ethoxymethylenemalonate

Downstream raw materials:

7-methoxyquinoline-3-carboxylic acid

7-hydroxyquinoline-3-carboxylic acid