methyl 1-phenyl-1H-pyrazole-3-carboxylate

Base Information

• Chemical Name: methyl 1-phenyl-1H-pyrazole-3-carboxylate
• CAS No.: 7188-95-6
• Molecular Formula: C11H10N2O2
• Molecular Weight: 202.213
• Mol file: 7188-95-6.mol

Synonyms:1-Phenyl-pyrazol-carbonsaeure-(3)-methylester;1-phenyl-1H-pyrazole-3-carboxylic acid methyl ester;Methyl-1-phenyl-pyrazol-3-carboxylat;1-Phenyl-pyrazol-carbonsaeure-3-methylester;1-Phenyl-pyrazolcarbonsaeure-3-methylester;1-Phenyl-1H-pyrazol-3-carbonsaeure-methylester;

Chemical Property of methyl 1-phenyl-1H-pyrazole-3-carboxylate

Chemical Property:

• Melting Point: 74-75 °C
• Boiling Point: 316.7±15.0 °C(Predicted)
• PKA: -2.52±0.10(Predicted)
• PSA: 44.12000
• Density: 1.18±0.1 g/cm3(Predicted)
• LogP: 1.65890

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of methyl 1-phenyl-1H-pyrazole-3-carboxylate

There total 9 articles about methyl 1-phenyl-1H-pyrazole-3-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.0%

iodobenzene (591-50-4) + methyl 1H-pyrazole 3-carboxylate (15366-34-4) → methyl 1-phenyl-1H-pyrazole-3-carboxylate (7188-95-6)

Guidance literature:

With trans-N,N'-dimethyl-1,2-cyclohexyldiamine; potassium phosphate; copper(l) iodide; In toluene; at 110 ℃; for 16h; Inert atmosphere;

DOI:10.1021/jm9012278

Reference yield: 51.0%

methanol (67-56-1) + 1-phenyl-1H-pyrazole-3-carboxylic acid (4747-46-0) → methyl 1-phenyl-1H-pyrazole-3-carboxylate (7188-95-6)

Guidance literature:

With diazomethyl-trimethyl-silane; at 0 - 20 ℃; for 2h;

Reference yield: 25.0%

PVS (5535-48-8) + methyl 2-chloro-2-(2-phenylhydrazono)acetate (58131-64-9) → methyl 1-phenyl-1H-pyrazole-3-carboxylate (7188-95-6) + 1,2-bis(phenylsulfonyl)ethane (599-94-0)

Guidance literature:

With triethylamine; In chloroform; for 40h; Ambient temperature;

DOI:10.1021/jo00206a044

upstream raw materials:

diazomethane

1-phenyl-1H-pyrazole-3-carboxylic acid

methanol

1-phenyl-3-trichloromethyl-1H-pyrazole

Downstream raw materials:

1-phenyl-1H-pyrazole-3-carboxylic acid

(1-phenyl-1H-pyrazol-3-yl)-methanol

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