(E)-4-(4-Methoxystyryl)pyridine

Base Information

• Chemical Name: (E)-4-(4-Methoxystyryl)pyridine
• CAS No.: 722-21-4
• Molecular Formula: C₁₄H₁₃NO
• Molecular Weight: 211.263
• Mol file: 722-21-4.mol

Synonyms:

Chemical Property of (E)-4-(4-Methoxystyryl)pyridine

Chemical Property:

• Melting Point: 128 °C
• Boiling Point: 363.0±11.0 °C(Predicted)
• PKA: 6.03±0.10(Predicted)
• PSA: 22.12000
• Density: 1.112±0.06 g/cm3(Predicted)
• LogP: 3.26060

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of (E)-4-(4-Methoxystyryl)pyridine

There total 18 articles about (E)-4-(4-Methoxystyryl)pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

4-vinylpyridine (100-43-6,329041-72-7) + para-iodoanisole (696-62-8) → (E)-4-(4-methoxystyryl)pyridine (722-21-4,6043-46-5,46739-60-0)

Guidance literature:

With potassium carbonate; cross-linked Pd-plug; In N,N-dimethyl-formamide; at 115 ℃;

DOI:10.1039/b711978j

Reference yield: 95.0%

4-((benzenesulfonyl)methyl)pyridine (1620-52-6) + 4-Methoxybenzyl alcohol (105-13-5) → (E)-4-(4-methoxystyryl)pyridine (722-21-4,6043-46-5,46739-60-0)

Guidance literature:

With sodium hydride; In mineral oil; at 135 ℃; for 16h; Inert atmosphere; Schlenk technique;

DOI:10.1039/c5cc01965f

Reference yield: 93.0%

4-vinylpyridine (100-43-6,329041-72-7) + 1-bromo-4-methoxy-benzene (104-92-7) → (E)-4-(4-methoxystyryl)pyridine (722-21-4,6043-46-5,46739-60-0)

Guidance literature:

With C₁₈H₂₁N₃O₂Pd; tetrabutylammomium bromide; caesium carbonate; In N,N-dimethyl acetamide; at 150 ℃; for 15h; Sealed tube;

DOI:10.1016/j.tet.2013.10.078

upstream raw materials:

picoline

4-methoxy-benzaldehyde

4-vinylpyridine

para-iodoanisole

Downstream raw materials:

4-(2-[p-methoxyphenyl]ethyl)piperidine

Refernces

• 1、 Cao, Chao-Tun,Yan, Lu,Cao, Chenzhong. "Determination and application of the excited-state substituent constants of pyridyl and substituted phenyl groups". . . Retrieved 2021/05/21.
• 2、 Baheti, Abhishek,Vigalok, Arkadi. "Short Wavelength Inner Filter Technique (SWIFT) in Designing Reactive Fluorescent Molecular Probes". supporting information. p. 12224 - 12228. Retrieved 2019/08/21.