methyl N-(4-acetylphenyl)carbamate

Base Information

• Chemical Name: methyl N-(4-acetylphenyl)carbamate
• CAS No.: 60677-43-2
• Molecular Formula: C10H11 N O3
• Molecular Weight: 193.202
• NSC Number: 177022
• DSSTox Substance ID: DTXSID20306511
• Nikkaji Number: J2.058.060G
• Wikidata: Q82053648
• Mol file: 60677-43-2.mol

Synonyms:60677-43-2;methyl N-(4-acetylphenyl)carbamate;NSC177022;methyl-4-acetylphenylcarbamate;SCHEMBL2094519;Methyl (4-acetylphenyl)carbamate;DTXSID20306511;DQFHKHFFKZUKEP-UHFFFAOYSA-N;AKOS000209870;NSC-177022

Chemical Property of methyl N-(4-acetylphenyl)carbamate

Chemical Property:

• Vapor Pressure: 0.00444mmHg at 25°C
• Refractive Index: 1.565
• Boiling Point: 277.7°Cat760mmHg
• Flash Point: 121.8°C
• Density: 1.204g/cm³
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 193.07389321
• Heavy Atom Count: 14
• Complexity: 219

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)C1=CC=C(C=C1)NC(=O)OC

Technology Process of methyl N-(4-acetylphenyl)carbamate

There total 12 articles about methyl N-(4-acetylphenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

p-aminobenzophenone (99-92-3) + methyl chloroformate (79-22-1) → methyl N-(4-acetylphenyl)carbamate (60677-43-2)

Guidance literature:

With pyridine; In acetone; for 3h; Reflux;

DOI:10.3390/molecules22122100

Reference yield: 73.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + p-aminobenzophenone (99-92-3) → methyl N-(4-acetylphenyl)carbamate (60677-43-2)

Guidance literature:

With copper diacetate; palladium diacetate; potassium iodide; In dimethyl sulfoxide; at 120 ℃; under 760.051 Torr;

DOI:10.1002/adsc.201100545

Reference yield: 72.0%

hydrazinecarboxylic acid methyl ester (6294-89-9) + p-aminobenzophenone (99-92-3) → methyl N-(4-acetylphenyl)carbamate (60677-43-2)

Guidance literature:

With tert.-butylhydroperoxide; copper(ll) bromide; In water; acetonitrile; at 20 ℃; for 4h; Sealed tube; Schlenk technique;

DOI:10.1021/acs.joc.1c01031

upstream raw materials:

p-aminobenzophenone

methyl chloroformate

methanol

phenyl isocyanate

Downstream raw materials:

mono-N-methylaminoacetophenone

p-aminobenzophenone