Quinoline, 6-[(2S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-2-[[(1,1-dimethylethyl)di methylsilyl]oxy]propyl]-8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

Base Information

Chemical Name:Quinoline, 6-[(2S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-2-[[(1,1-dimethylethyl)di methylsilyl]oxy]propyl]-8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-
CAS No.:834906-33-1
Molecular Formula:C45H59NO5Si2
Molecular Weight:750.138
Hs Code.:

Quinoline,
6-[(2S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-2-[[(1,1-dimethylethyl)di
methylsilyl]oxy]propyl]-8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

Synonyms:

Suppliers and Price of Quinoline, 6-[(2S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-2-[[(1,1-dimethylethyl)di methylsilyl]oxy]propyl]-8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of Quinoline, 6-[(2S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-2-[[(1,1-dimethylethyl)di methylsilyl]oxy]propyl]-8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

Chemical Property:

PSA：59.04000
LogP:11.57760

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of Quinoline, 6-[(2S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-2-[[(1,1-dimethylethyl)di methylsilyl]oxy]propyl]-8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]-

There total 5 articles about Quinoline, 6-[(2S)-3-[bis(4-methoxyphenyl)phenylmethoxy]-2-[[(1,1-dimethylethyl)di methylsilyl]oxy]propyl]-8-[[(1,1-dimethylethyl)dimethylsilyl]oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 18162-48-6
tert-butyldimethylsilyl chloride

: 834906-32-0
1-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-3-[8-(tert-butyl-dimethyl-silanyloxy)-quinolin-6-yl]-propan-2-ol

: 834906-33-1
6-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-8-(tert-butyl-dimethyl-silanyloxy)-quinoline

Guidance literature:: With 1H-imidazole; dmap; In dichloromethane; at 20 ℃; for 2h;
DOI:10.1021/ja043904j

Reference yield:

: 139399-64-7
6-bromo-8-quinolinol

: 834906-33-1
6-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-8-(tert-butyl-dimethyl-silanyloxy)-quinoline

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / imidazole / dimethylformamide / 20 °C

2: 87 percent / imidazole; DMAP / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; dmap; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja043904j

Reference yield:

: 103028-32-6
6-bromo-8-methoxy-quinoline

: 834906-33-1
6-[3-[bis-(4-methoxy-phenyl)-phenyl-methoxy]-2-(tert-butyl-dimethyl-silanyloxy)-propyl]-8-(tert-butyl-dimethyl-silanyloxy)-quinoline

Guidance literature:: Multi-step reaction with 4 steps

1: 77 percent / aq. HBr / 36 h / Heating

2: 55 percent / imidazole / dimethylformamide / 20 °C

3: 87 percent / imidazole; DMAP / CH₂Cl₂ / 2 h / 20 °C

With 1H-imidazole; dmap; hydrogen bromide; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/ja043904j