2-[2-(Methylamino)ethoxy]ethan-1-ol

Base Information

• Chemical Name: 2-[2-(Methylamino)ethoxy]ethan-1-ol
• CAS No.: 85475-01-0
• Molecular Formula: C5H13NO2
• Molecular Weight: 119.164
• European Community (EC) Number: 859-410-0
• DSSTox Substance ID: DTXSID70573539
• Wikidata: Q82462280
• Mol file: 85475-01-0.mol

Synonyms:85475-01-0;2-[2-(methylamino)ethoxy]ethan-1-ol;Hydroxy-PEG1-methylamine;2-(2-(methylamino)ethoxy)ethanol;2-[2-(METHYLAMINO)ETHOXY]ETHANOL;MFCD12783671;2-(2-(methylamino)ethoxy)ethan-1-ol;Ethanol, 2-[2-(methylamino)ethoxy]-;MeNH-PEG2-OH;SCHEMBL40114;DTXSID70573539;2-(2-Methylamino-ethoxy)-ethanol;2-(2-(Methylamino)-ethoxy)ethanol;AKOS009068635;BT-0169;BP-22918;SY199087;CS-0209922;C70229;EN300-200831

Chemical Property of 2-[2-(Methylamino)ethoxy]ethan-1-ol

Chemical Property:

• Boiling Point: 90-91 °C(Press: 4.5 Torr)
• PKA: 14.40±0.10(Predicted)
• PSA: 41.49000
• Density: 0.962±0.06 g/cm3(Predicted)
• LogP: -0.39440
• XLogP3: -1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 5
• Exact Mass: 119.094628657
• Heavy Atom Count: 8
• Complexity: 41.4

Purity/Quality:

97% ^*data from raw suppliers

Hydroxy-PEG1-methylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNCCOCCO
• Description: Hydroxy-PEG1-methylamine is a PEG linker containing a hydroxyl group with a methylamine group. The hydrophilic PEG spacer increases solubility in aqueous media. The hydroxyl group enables further derivatization or replacement with other reactive functional groups. The methylamine group is reactive with carboxylic acids, carbonyls (ketone, aldehyde) etc.

Technology Process of 2-[2-(Methylamino)ethoxy]ethan-1-ol

There total 2 articles about 2-[2-(Methylamino)ethoxy]ethan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

methanol (67-56-1) + 2-(2-Aminoethoxy)ethanol (929-06-6) → morpholine (110-91-8,99108-56-2) + 1-O-Dimethylaminoethyl-ethylenglykol (1704-62-7) + N-methyl-2-(2-hydroxyethoxy)ethylamine (85475-01-0)

Guidance literature:

With Cs-P-Si mixed-oxide; at 300 ℃; under 61504.9 Torr; Title compound not separated from byproducts;

DOI:10.1002/1521-3773(20020916)41:18<3476::AID-ANIE3476>3.0.CO;2-5

Reference yield:

2-(2-Chloroethoxy)ethanol (628-89-7) + methylamine (74-89-5) → N-methyl-2-(2-hydroxyethoxy)ethylamine (85475-01-0) + N-methyl-6-aza-3,9-dioxaundecane-1,11-diol (254448-29-8)

Guidance literature:

at 55 - 100 ℃; unter Druck;

DOI:10.1039/jr9470000530

Reference yield: 76.0%

N-methyl-2-(2-hydroxyethoxy)ethylamine (85475-01-0) + C66H86Cl2N10O4 → C76H110N12O8

Guidance literature:

at 70 ℃;

DOI:10.1039/c9sc05354a

upstream raw materials:

2-(2-Chloroethoxy)ethanol

methylamine

methanol

2-(2-Aminoethoxy)ethanol

Downstream raw materials:

2-(2-{[2-(2-hydroxyethoxy)ethyl](methyl)amino}ethoxy)ethyl (2E)-3-(3,4,5-trimethoxyphenyl)prop-2-enoate