N-(5-Chloro-pyridin-2-yl)-2,2-dimethylpropanamide

Base Information

• Chemical Name: N-(5-Chloro-pyridin-2-yl)-2,2-dimethylpropanamide
• CAS No.: 86847-83-8
• Molecular Formula: C10H13ClN2O
• Molecular Weight: 212.679
• Mol file: 86847-83-8.mol

Synonyms:N-(5-chloropyridin-2-yl)-2,2-dimethylpropionamide;2-N-pivaloylamido-5-chloropyridine;N-(5-chloropyridin-2-yl)-2,2-dimethylpropanamide;N-(5-chloro-2-pyridyl)-2,2-dimethylpropanamide;N-(5-chloro-2-pyridinyl)-2,2-dimethylpropanamide;2,2-Dimethyl-N-(5-chloro-2-pyridinyl)propanamide;

Chemical Property of N-(5-Chloro-pyridin-2-yl)-2,2-dimethylpropanamide

Chemical Property:

• PSA: 41.99000
• LogP: 2.79260

Purity/Quality:

99% ^*data from raw suppliers

N-(5-chloropyridin-2-yl)-2,2-dimethylpropanamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N-(5-Chloro-pyridin-2-yl)-2,2-dimethylpropanamide

There total 4 articles about N-(5-Chloro-pyridin-2-yl)-2,2-dimethylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

5-chloro-2-pyridylamine (1072-98-6) + pivaloyl chloride (3282-30-2) → N-(5-Chloro-pyridin-2-yl)-2,2-dimethylpropanamide (86847-83-8)

Guidance literature:

With dmap; triethylamine; In dichloromethane; at 0 - 20 ℃;

DOI:10.1021/ol401540k

Reference yield: 53.0%

2-(pivaloylamino)pyridine (86847-59-8) → N-(5-Chloro-pyridin-2-yl)-2,2-dimethylpropanamide (86847-83-8)

Guidance literature:

With tetraethylammonium chloride; trichloroacetonitrile; In acetonitrile; at 23 ℃; for 2h; Electrochemical reaction; Inert atmosphere;

DOI:10.1021/acs.orglett.1c00704

Reference yield: 39.0%

(1-Benzotriazol-1-yl-2,2-dimethyl-propyl)-(5-chloro-pyridin-2-yl)-amine (121953-45-5) → N-(5-Chloro-pyridin-2-yl)-2,2-dimethylpropanamide (86847-83-8) + N-tert-Butyl-N-(5-chloro-pyridin-2-yl)-formamide (121953-56-8)

Guidance literature:

With selenium(IV) oxide; dihydrogen peroxide; In methanol; for 6h; Heating;

upstream raw materials:

5-chloro-2-pyridylamine

pivaloyl chloride

(1-Benzotriazol-1-yl-2,2-dimethyl-propyl)-(5-chloro-pyridin-2-yl)-amine

2-(pivaloylamino)pyridine

Downstream raw materials:

(2-amino-5-chloropyridin-3-yl)(phenyl)methanone