N,N-Dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethanamine

Base Information

• Chemical Name: N,N-Dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethanamine
• CAS No.: 873078-93-4
• Molecular Formula: C16H26BNO3
• Molecular Weight: 291.198
• Hs Code.: 2934999090
• Mol file: 873078-93-4.mol

Synonyms:N,N-dimethyl-2-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy]ethanamine;

Chemical Property of N,N-Dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethanamine

Chemical Property:

• PSA: 30.93000
• LogP: 1.92620
• Storage Temp.: 2-8°C

Purity/Quality:

98%,99%, ^*data from raw suppliers

4-(2-(Dimethylamino)ethoxy)phenylboronicacid,pinacolester ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of N,N-Dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethanamine

There total 4 articles about N,N-Dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

[2-(4-bromophenoxy)ethyl]dimethylamine (2474-07-9) + bis(pinacol)diborane (73183-34-3) → N,N-dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethan-1-amine (873078-93-4)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; potassium carbonate; In 1,2-dimethoxyethane; at 100 ℃; for 15h; Inert atmosphere;

Reference yield: 86.0%

(2-chloroethyl)dimethylamine hydrochloride (4584-46-7) + 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (269409-70-3) → N,N-dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethan-1-amine (873078-93-4)

Guidance literature:

With caesium carbonate; In tetrahydrofuran; at 130 ℃; for 2h; Microwave irradiation;

Reference yield: 29.0%

2-(dimethylamino)ethyl chloride (107-99-3) + 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol (269409-70-3) → N,N-dimethyl-2-(4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenoxy)ethan-1-amine (873078-93-4)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 60 ℃;

upstream raw materials:

2-(N,N-dimethylamino)ethanol

4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenol

[2-(4-bromophenoxy)ethyl]dimethylamine

bis(pinacol)diborane

Refernces

• 1、 -. "PYRROLO [2, 3-B] PYRIDINES OR PYRROLO [2, 3-B] PYRAZINES AS HPK1 INHIBITOR AND THE USE THEREOF". Paragraph 0401; 0874-0876. . Retrieved 2020/01/08.
• 2、 -. "SUBSTITUTED PYRIDOPYRAZINES AS NOVEL SYK INHIBITORS". Paragraph 0156; 0157. . Retrieved 2014/05/08.