N-[N-[(Phenylmethoxy)carbonyl]glycyl]-L-methionine

Base Information

• Chemical Name: N-[N-[(Phenylmethoxy)carbonyl]glycyl]-L-methionine
• CAS No.: 3561-48-6
• Molecular Formula: C15H20 N2 O5 S
• Molecular Weight: 340.4
• Hs Code.: 2930909090
• European Community (EC) Number: 222-623-9
• DSSTox Substance ID: DTXSID901219198
• Nikkaji Number: J216.202D
• Mol file: 3561-48-6.mol

Synonyms:3561-48-6;Z-GLY-MET-OH;N-[N-[(Phenylmethoxy)carbonyl]glycyl]-L-methionine;EINECS 222-623-9;(2S)-4-methylsulfanyl-2-[[2-(phenylmethoxycarbonylamino)acetyl]amino]butanoic acid;N-(N-((Phenylmethoxy)carbonyl)glycyl)-L-methionine;C15H20N2O5S;(S)-2-(2-(((Benzyloxy)carbonyl)amino)acetamido)-4-(methylthio)butanoic acid;L-Methionine, N-(N-((phenylmethoxy)carbonyl)glycyl)-;L-Methionine, N-[N-[(phenylmethoxy)carbonyl]glycyl]-;SCHEMBL9831185;D-Valinemethyl esterhydrochloride;DTXSID901219198;MFCD00056134;AKOS024337591;NSC 169155;(2S)-2-[({[(benzyloxy)carbonyl]amino}acetyl)amino]-4-(methylthio)butanoic acid

Chemical Property of N-[N-[(Phenylmethoxy)carbonyl]glycyl]-L-methionine

Chemical Property:

• Vapor Pressure: 1.72E-17mmHg at 25°C
• Boiling Point: 644.5°Cat760mmHg
• Flash Point: 343.6°C
• PSA: 130.03000
• Density: 1.284g/cm³
• LogP: 2.01710
• Storage Temp.: -15°C
• XLogP3: 1.4
• Hydrogen Bond Donor Count: 3
• Hydrogen Bond Acceptor Count: 6
• Rotatable Bond Count: 10
• Exact Mass: 340.10929292
• Heavy Atom Count: 23
• Complexity: 399

Purity/Quality:

99% ^*data from raw suppliers

Z-Gly-Met-OH ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CSCCC(C(=O)O)NC(=O)CNC(=O)OCC1=CC=CC=C1
• Isomeric SMILES: CSCC[C@@H](C(=O)O)NC(=O)CNC(=O)OCC1=CC=CC=C1

Technology Process of N-[N-[(Phenylmethoxy)carbonyl]glycyl]-L-methionine

There total 3 articles about N-[N-[(Phenylmethoxy)carbonyl]glycyl]-L-methionine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

Met-OMe (10332-17-9,874219-77-9) + N-(benzyloxycarbonyl)glycyl chloride (15050-24-5) → N-(N-benzyloxycarbonyl-glycyl)-L-methionine (3561-48-6)

Guidance literature:

With diethyl ether; potassium hydrogencarbonate; at 0 ℃; Behandeln des Reaktionsprodukts mit wss.-aethanol. NaOH;

Reference yield:

N-(Benzyloxycarbonyl)glycine (1138-80-3) → N-(N-benzyloxycarbonyl-glycyl)-L-methionine (3561-48-6)

Guidance literature:

Multi-step reaction with 2 steps

1: (i) aq. NaOH, AcOEt, Py, (ii) /BRN= 4171999/, aq. HCl

2: (i) 4N>OH, (ii) /BRN= 3040634/, N,N,N',N'-tetramethyl-guanidine, DMSO

DOI:10.1016/S0040-4020(01)97372-7

Reference yield:

L-methionine (63-68-3,26062-47-5,58576-49-1) + Benzyloxycarbonylamino-acetic acid 3-ethylcarbamoyl-2-hydroxy-phenyl ester (16859-24-8) → N-(N-benzyloxycarbonyl-glycyl)-L-methionine (3561-48-6)

Guidance literature:

Multistep reaction; (i) OH, (ii) /BRN= 3040634/, N,N,N',N'-tetramethyl-guanidine, DMSO;

DOI:10.1016/S0040-4020(01)97372-7

upstream raw materials:

Met-OMe

N-(benzyloxycarbonyl)glycyl chloride

L-methionine

Benzyloxycarbonylamino-acetic acid 3-ethylcarbamoyl-2-hydroxy-phenyl ester

Downstream raw materials:

Gly-Met