3,6-Dimethoxy-4-methylpyridazine

Base Information

• Chemical Name: 3,6-Dimethoxy-4-methylpyridazine
• CAS No.: 89943-29-3
• Molecular Formula: C₇H₁₀N₂O₂
• Molecular Weight: 154.169
• Mol file: 89943-29-3.mol

Synonyms:4-Methyl-3,6-dimethoxy-pyridazin;3,6-Dimethoxy-4-methyl-pyridazine;3,6-Dimethoxy-4-methyl-pyridazin;

Chemical Property of 3,6-Dimethoxy-4-methylpyridazine

Chemical Property:

• Melting Point: 85 - 86 °C
• PSA: 44.24000
• LogP: 0.80220

Purity/Quality:

97% ^*data from raw suppliers

3,6-Dimethoxy-4-methyl-pyridazine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,6-Dimethoxy-4-methylpyridazine

There total 4 articles about 3,6-Dimethoxy-4-methylpyridazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3,6-dichloro-4-methylpyridazine (19064-64-3) + sodium methylate (124-41-4) → 4-Methyl-3,6-dimethoxy-pyridazin (89943-29-3)

Guidance literature:

With methanol; at 120 - 130 ℃;

DOI:10.1002/hlca.19540370115

Reference yield:

3,6-dimethoxypyridazine (4603-59-2) + methyl iodide (74-88-4) → 4-Methyl-3,6-dimethoxy-pyridazin (89943-29-3)

Guidance literature:

With 2,2,6,6-tetramethylpiperidinyl-lithium; Yield given. Multistep reaction; 1) hexane, THF, -78 deg C, 15 min, 2) -78 deg C -> rt;

DOI:10.1021/jo00297a085

Reference yield:

4-methyl-1,2-dihydropyridazine-3,6-dione (5754-18-7) → 4-Methyl-3,6-dimethoxy-pyridazin (89943-29-3)

Guidance literature:

Multi-step reaction with 2 steps

1: POCl₃

2: methanol / 120 - 130 °C

With methanol; trichlorophosphate;

DOI:10.1002/hlca.19540370115

upstream raw materials:

3,6-dichloro-4-methylpyridazine

sodium methylate

3,6-dimethoxypyridazine

methyl iodide