8-methyl-7H-purin-6-amine

Base Information

• Chemical Name: 8-methyl-7H-purin-6-amine
• CAS No.: 22387-37-7
• Molecular Formula: C6H7 N5
• Molecular Weight: 149.155
• Hs Code.: 2933990090
• NSC Number: 22744
• DSSTox Substance ID: DTXSID00176916
• Nikkaji Number: J83.179D
• Wikidata: Q83047247
• ChEMBL ID: CHEMBL62647
• Mol file: 22387-37-7.mol

Synonyms:8-methyladenine

Chemical Property of 8-methyl-7H-purin-6-amine

Chemical Property:

• Vapor Pressure: 0.00191mmHg at 25°C
• Melting Point: 335 °C (decomp)
• Boiling Point: 495°Cat760mmHg
• PKA: 9.86±0.20(Predicted)
• Flash Point: 285.3°C
• PSA: 80.48000
• Density: 1.49g/cm³
• LogP: 0.82470
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 1
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 149.07014524
• Heavy Atom Count: 11
• Complexity: 150

Purity/Quality:

97% ^*data from raw suppliers

8-Methyl-7H-purin-6-amine 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC2=NC=NC(=C2N1)N

Technology Process of 8-methyl-7H-purin-6-amine

There total 10 articles about 8-methyl-7H-purin-6-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

6-amino-8-methyl-9-(tetrahydropyran-2-yl)purine (713140-78-4) → 8-methyl-9H-purin-6-ylamine (22387-37-7)

Guidance literature:

With Dowex 50WX₈ (H(+)); In ethanol; for 1h; Heating;

DOI:10.1055/s-2004-816012

Reference yield: 82.0%

acetamide (60-35-5) + 4,5,6-triaminopyrimidine sulfate (49721-45-1) → 8-methyl-9H-purin-6-ylamine (22387-37-7)

Guidance literature:

at 230 ℃; for 6h;

DOI:10.1021/jm00170a005

Reference yield: 43.0%

dihydroxy-methyl-borane (13061-96-6) + 8-bromoadenine (6974-78-3) → 8-methyl-9H-purin-6-ylamine (22387-37-7)

Guidance literature:

With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; potassium carbonate; In 1,4-dioxane; water; at 95 ℃; Inert atmosphere;

upstream raw materials:

acetic anhydride

4,5,6-triaminopyrimidine

ethanol

6-chloro-8-methyl-7H-purine

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