ethyl [4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]-pyrimidin-2-yl]amino}phenyl)piperazin-1-yl]acetate

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Chemical Name:ethyl [4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]-pyrimidin-2-yl]amino}phenyl)piperazin-1-yl]acetate
CAS No.:909561-13-3
Molecular Formula:C₂₇H₂₈F₂N₆O₂
Molecular Weight:506.555
Hs Code.:

Synonyms:ethyl [4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]-pyrimidin-2-yl]amino}phenyl)piperazin-1-yl]acetate

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Chemical Property of ethyl [4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]-pyrimidin-2-yl]amino}phenyl)piperazin-1-yl]acetate

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Technology Process of ethyl [4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]-pyrimidin-2-yl]amino}phenyl)piperazin-1-yl]acetate

There total 11 articles about ethyl [4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]-pyrimidin-2-yl]amino}phenyl)piperazin-1-yl]acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 7-(3,5-difluorobenzyl)-N-(4-piperazin-1-ylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine dihydrochloride

: 105-36-2
ethyl bromoacetate

: 909561-13-3
ethyl [4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]-pyrimidin-2-yl]amino}phenyl)piperazin-1-yl]acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 4h;
DOI:10.1016/j.bmc.2009.08.021

Reference yield:

: 909564-40-5
7-(3,5-difluorobenzyl)-N-(4-piperazin-1-ylphenyl)-7H-pyrrolo[2,3-d]pyrimidin-2-amine

: 105-36-2
ethyl bromoacetate

: 909561-13-3
ethyl [4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]-pyrimidin-2-yl]amino}phenyl)piperazin-1-yl]acetate

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 100 ℃; for 4h;

Reference yield:

: 2,4-dichloro-6-iodo-7H-pyrrolo[2,3-d]pyrimidine

: 909561-13-3
ethyl [4-(4-{[7-(3,5-difluorobenzyl)-7H-pyrrolo[2,3-d]-pyrimidin-2-yl]amino}phenyl)piperazin-1-yl]acetate

Guidance literature:: Multi-step reaction with 8 steps

1: potassium carbonate; palladium on activated charcoal; hydrogen / ethanol / 4 h

2: dmap; triethylamine / ethanol / 0.5 h

3: palladium on activated charcoal; hydrogen; triethylamine / ethanol

4: trifluoroacetic acid / dichloromethane / 3 h

5: potassium carbonate / dimethyl sulfoxide / 2 h / 60 °C

6: caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; palladium diacetate / 1,4-dioxane / 3 h / 80 °C

7: hydrogenchloride / water; methanol; tetrahydrofuran; ethyl acetate / 13 h / 80 °C

8: potassium carbonate / N,N-dimethyl-formamide / 4 h / 100 °C

With hydrogenchloride; dmap; palladium on activated charcoal; hydrogen; palladium diacetate; potassium carbonate; caesium carbonate; 2,2'-bis-(diphenylphosphino)-1,1'-binaphthyl; triethylamine; trifluoroacetic acid; In tetrahydrofuran; 1,4-dioxane; methanol; ethanol; dichloromethane; water; dimethyl sulfoxide; ethyl acetate; N,N-dimethyl-formamide;