4-Fluoro-6-methoxy-2-methyl-5-(trifluoromethyl)pyrimidine

Base Information

• Chemical Name: 4-Fluoro-6-methoxy-2-methyl-5-(trifluoromethyl)pyrimidine
• CAS No.: 97653-57-1
• Molecular Formula: C7H6F4N2O
• Molecular Weight: 210.131
• DSSTox Substance ID: DTXSID90538761
• Wikidata: Q82414293

Synonyms:4-Fluoro-6-methoxy-2-methyl-5-(trifluoromethyl)pyrimidine;97653-57-1;SCHEMBL7229115;DTXSID90538761;4-fluoro-6-methoxy-2-methyl-5-(trifluoromethyl)-pyrimidine

Chemical Property of 4-Fluoro-6-methoxy-2-methyl-5-(trifluoromethyl)pyrimidine

Chemical Property:

• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 7
• Rotatable Bond Count: 1
• Exact Mass: 210.04162547
• Heavy Atom Count: 14
• Complexity: 199

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC1=NC(=C(C(=N1)F)C(F)(F)F)OC

Technology Process of 4-Fluoro-6-methoxy-2-methyl-5-(trifluoromethyl)pyrimidine

There total 1 articles about 4-Fluoro-6-methoxy-2-methyl-5-(trifluoromethyl)pyrimidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 5.0%

1,3,3,3-tetrafluoro-1-methoxy-2-trifluoromethyl-propene (360-53-2) + acetamidine hydrochloride (124-42-5) → 1,1,1,3,3-pentafluoro-3-methoxy-2-trifluoromethylpropane (382-26-3) + 2-methyl-4-fluoro-5-trifluoromethyl-6-methoxypyrimidine (97653-57-1)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; Ambient temperature; different solvents and bases;

DOI:10.1016/S0022-1139(00)84991-X

Reference yield: 83.0%

diethylamine (109-89-7) + 2-methyl-4-fluoro-5-trifluoromethyl-6-methoxypyrimidine (97653-57-1) → Diethyl-(6-methoxy-2-methyl-5-trifluoromethyl-pyrimidin-4-yl)-amine

Guidance literature:

In diethyl ether; at 0 ℃; for 0.5h; general reaction;

DOI:10.1016/S0022-1139(00)84991-X

Reference yield: 57.0%

2-methyl-4-fluoro-5-trifluoromethyl-6-methoxypyrimidine (97653-57-1) + phenol (108-95-2,27073-41-2) → 4-Methoxy-2-methyl-6-phenoxy-5-trifluoromethyl-pyrimidine

Guidance literature:

In diethyl ether; at 0 ℃; for 0.5h;

DOI:10.1016/S0022-1139(00)84991-X

upstream raw materials:

1,3,3,3-tetrafluoro-1-methoxy-2-trifluoromethyl-propene

acetamidine hydrochloride

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