4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

Base Information

• Chemical Name: 4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-4(3H)-one
• CAS No.: 39786-36-2
• Molecular Formula: C10H6N2O2
• Molecular Weight: 186.17
• Hs Code.: 2934999090
• Mol file: 39786-36-2.mol

Synonyms:3H-Benzo[4,5]furo[3,2-d]pyrimidin-4-one;3-Hydrobenzo[d]pyrimidino[5,4-b]furan-4-one;

Chemical Property of 4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

Chemical Property:

• Vapor Pressure: 8.29E-06mmHg at 25°C
• Melting Point: 277℃
• Refractive Index: 1.749
• Boiling Point: 374.5 °C at 760 mmHg
• Flash Point: 180.3 °C
• PSA: 59.15000
• Density: 1.53 g/cm³
• LogP: 2.08160
• Storage Temp.: 2-8°C

Purity/Quality:

97% ^*data from raw suppliers

[1]Benzofuro[3,2-d]pyrimidin-4-ol ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-4(3H)-one

There total 15 articles about 4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-oxo-3,4-dihydro[1]benzofuro[3,2-d]pyrimidine-2-carboxylic acid (1144105-32-7) → 4-oxo-3,4-dihydrobenzofuro<3,2-d>pyrimidine (39786-36-2)

Guidance literature:

In dimethyl sulfoxide; Heating;

DOI:10.1016/j.mencom.2008.07.018

Reference yield: 86.0%

3-aminobenzofuran-2-carboxamide (54802-10-7) + trimethyl orthoformate (149-73-5) → benzofuro[3,2-d]pyrimidin-4-ol (39786-36-2)

Guidance literature:

at 150 ℃; for 2h;

Reference yield: 62.0%

methanol (67-56-1) + 3-aminobenzofuran-2-carboxamide (54802-10-7) → 4-oxo-3,4-dihydrobenzofuro<3,2-d>pyrimidine (39786-36-2)

Guidance literature:

With oxygen; copper(II) acetate monohydrate; caesium carbonate; at 110 ℃; for 24h;

DOI:10.1002/ejoc.202000257

upstream raw materials:

4-Chlorobenzofuro<3,2-d>pyrimidine

3-aminobenzofuran-2-carboxamide

formamide

ethyl 3-aminobenzofuran-2-carboxylate

Downstream raw materials:

4-Chlorobenzofuro<3,2-d>pyrimidine

4-benzylsulfanyl-benzo[4,5]furo[3,2-d]pyrimidine