4,4,4-Trichlorobutyric acid methyl ester

Base Information

• Chemical Name: 4,4,4-Trichlorobutyric acid methyl ester
• CAS No.: 19376-57-9
• Molecular Formula: C5H7 Cl3 O2
• Molecular Weight: 205.468
• Hs Code.: 2915907098
• Mol file: 19376-57-9.mol

Synonyms:Butyricacid, 4,4,4-trichloro-, methyl ester (6CI,8CI); Methyl4,4,4-trichlorobutanoate; Methyl 4,4,4-trichlorobutyrate; NSC 299171

Chemical Property of 4,4,4-Trichlorobutyric acid methyl ester

Chemical Property:

• Vapor Pressure: 0.181mmHg at 25°C
• Refractive Index: 1.4648
• Boiling Point: 211.6°C at 760 mmHg
• Flash Point: 83.5°C
• PSA: 26.30000
• Density: 1.381g/cm³
• LogP: 2.30980
• Storage Temp.: 2-8°C

Purity/Quality:

98% ^*data from raw suppliers

Methyl4,4,4-trichlorobutanoate ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 4,4,4-Trichlorobutyric acid methyl ester

There total 8 articles about 4,4,4-Trichlorobutyric acid methyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

chloroform (67-66-3,8013-54-5) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → Methyl β-trichloromethylpropionate (19376-57-9)

Guidance literature:

With N(Et)4⁽¹⁺⁾*(2-pyrrolidone-anion); In N,N-dimethyl-formamide; 1) 1h, -70 deg C, 2) 4h, r.t.;

DOI:10.1016/S0040-4039(00)97274-5

Reference yield:

chloroform (67-66-3,8013-54-5) + acrylic acid methyl ester (292638-85-8,9003-21-8,96-33-3) → ω,ω,ω-trichlorobutanoic acid (2345-32-6) + Methyl β-trichloromethylpropionate (19376-57-9)

Guidance literature:

With sodium hydroxide; Tetraphenylarsonium chloride; at 40 ℃; for 4h;

Reference yield:

methanol (67-56-1) + tetrachloromethane (56-23-5) + ethene (74-85-1) → Methyl β-trichloromethylpropionate (19376-57-9)

Guidance literature:

With di-tert-butyl peroxide; at 130 ℃; Edukt 4:Kohlenmonoxid;

DOI:10.1021/ja01602a039

upstream raw materials:

methanol

tetrachloromethane

ethene

methyl 2-bromo-4,4,4-trichlorobutanoate

Downstream raw materials:

ω,ω,ω-trichlorobutanoic acid

Refernces

• 1、 -. "ANDROGEN RECEPTOR MODULATORS AND METHODS FOR THEIR USE". Page/Page column 49; 50. . Retrieved 2015/12/18.
• 2、 Shono, Tatsuya,Ishifune, Manabu,Ishige, Osamu,Uyama, Hiroshi,Kashimura, Shigenori. "FORMATION OF A REASONABLY STABILIZED TRICHLOROMETHYL ANION BY THE REACTION OF CHLOROFORM WITH ELECTROGENERATED BASE, AND ITS 1,4-ADDITION TO α,β-UNSATURATED CARBONYL COMPOUNDS". . p. 7181 - 7184. Retrieved 2007/10/02.