3-Methoxy-n,n-dimethylbenzamide

Base Information

• Chemical Name: 3-Methoxy-n,n-dimethylbenzamide
• CAS No.: 7290-99-5
• Molecular Formula: C10H13NO2
• Molecular Weight: 179.219
• NSC Number: 122107
• DSSTox Substance ID: DTXSID60298269
• Nikkaji Number: J988.015A
• Wikidata: Q82039982
• Mol file: 7290-99-5.mol

Synonyms:3-methoxy-n,n-dimethylbenzamide;7290-99-5;NSC122107;SCHEMBL2540656;DTXSID60298269;HMS1703P19;3-CH3O-C6H4CON(CH3)2;AKOS000678016;NSC-122107;Z32014541

Chemical Property of 3-Methoxy-n,n-dimethylbenzamide

Chemical Property:

• Vapor Pressure: 0.000467mmHg at 25°C
• Boiling Point: 314.4°Cat760mmHg
• Flash Point: 144°C
• Density: 1.062g/cm³
• XLogP3: 1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 179.094628657
• Heavy Atom Count: 13
• Complexity: 180

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN(C)C(=O)C1=CC(=CC=C1)OC

Technology Process of 3-Methoxy-n,n-dimethylbenzamide

There total 12 articles about 3-Methoxy-n,n-dimethylbenzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

tris(dimethylamino)borane (4375-83-1) + 3-methoxy-benzaldehyde (591-31-1) → N,N-dimethyl-m-methoxybenzamide (7290-99-5)

Guidance literature:

With tert.-butylhydroperoxide; In acetonitrile; at 80 ℃; for 24h;

DOI:10.1021/ol7014626

Reference yield: 93.0%

3-methoxy-1-iodobenzene (766-85-8) + carbon monoxide (201230-82-2) + dimethyl amine (124-40-3) → N,N-dimethyl-m-methoxybenzamide (7290-99-5)

Guidance literature:

With palladium diacetate; triethylamine; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; hydrazine; In tetrahydrofuran; 1,4-dioxane; at 100 ℃; under 7500.75 Torr; Pressure; Concentration; Reagent/catalyst; Flow reactor;

DOI:10.1002/ejoc.201402804

Reference yield: 86.0%

methanol (67-56-1) + 3-methoxyphenyl bromide (2398-37-0) + N,N-dimethyl-formamide (68-12-2,33513-42-7) → methyl 3-methoxybenzoate (5368-81-0) + N,N-dimethyl-m-methoxybenzamide (7290-99-5)

Guidance literature:

3-methoxyphenyl bromide; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h;

N,N-dimethyl-formamide; In tetrahydrofuran; hexane; at -78 - 20 ℃; for 2h;

methanol; Further stages;

DOI:10.1016/j.tet.2012.04.016

upstream raw materials:

tetrakis(dimethylamino)silane

3-methoxy-benzaldehyde

tris(dimethylamino)borane

3-methoxyphenyl bromide

Downstream raw materials:

1-(3-methoxyphenyl)-3-phenylprop-2-yn-1-one

N-(Bis-trimethylsilanyl-methyl)-3-methoxy-N-methyl-benzamide

N,N-dimethyl-3-methoxybenzylamine

N,N-dimethyl-(2-bromo-5-methoxy)benzamide