Methyl L-lysinate dihydrochloride

Base Information

• Chemical Name: Methyl L-lysinate dihydrochloride
• CAS No.: 26348-70-9
• Molecular Formula: C₇H₁₇N₂O₂*Cl
• Molecular Weight: 196.677
• Hs Code.: 29224190
• European Community (EC) Number: 247-625-7
• DSSTox Substance ID: DTXSID00180952
• Mol file: 26348-70-9.mol

Synonyms:26348-70-9;L-Lysine methyl ester dihydrochloride;H-Lys-OMe.2HCl;Methyl L-lysinate dihydrochloride;L-Lysine methyl ester 2HCl;L-Lysine, methyl ester, dihydrochloride;Lysine, methyl ester, dihydrochloride;Methyl L-lysinate HCl;methyl (2S)-2,6-diaminohexanoate;dihydrochloride;[(2S)-6-Azaniumyl-1-methoxy-1-oxohexan-2-yl]azanium;dichloride;(S)-methyl 2,6-diaminohexanoate dihydrochloride;EINECS 247-625-7;MFCD00039067;L-Lys-OMe⋅2HCl;methyl lysinate dihydrochloride;methyl lysinate, dihydrochloride;SCHEMBL1041225;DTXSID00180952;SXZCBVCQHOJXDR-ILKKLZGPSA-N;lysine methyl ester dihydrochloride;NSC 83256;AKOS015845242;AKOS015894548;L -Lysine methyl ester dihydrochloride;AC-8660;AM81966;CS-W010347;HY-W009631;AS-12225;L0202;F10815;(S)-methyl 2,6-diaminohexanoate dihydrochloride;J-300191;W-107177

Chemical Property of Methyl L-lysinate dihydrochloride

Chemical Property:

• Vapor Pressure: 0.0313mmHg at 25°C
• Melting Point: 213-215 °C
• Refractive Index: 17 ° (C=5, H2O)
• Boiling Point: 243.9 °C at 760 mmHg
• Flash Point: 93.5 °C
• PSA: 78.34000
• Density: 1.031 g/cm³
• LogP: 2.62030
• Storage Temp.: −20°C
• Sensitive.: Hygroscopic
• Solubility.: Methanol, Water
• Water Solubility.: Soluble in water.
• Hydrogen Bond Donor Count: 4
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 6
• Exact Mass: 232.0745332
• Heavy Atom Count: 13
• Complexity: 117

Purity/Quality:

98% ^*data from raw suppliers

L-Lysine methyl ester dihydrochloride ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39-24/25

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Chemical Classes: Biological Agents -> Amino Acids and Derivatives
• Canonical SMILES: COC(=O)C(CCCCN)N.Cl.Cl
• Isomeric SMILES: COC(=O)[C@H](CCCCN)N.Cl.Cl
• Uses: L-Lysine methyl ester dihydrochloride is used in the production of lysine methyl ester based cationic surfactants and hydrogels. Methyl L-lysinate dihydrochloride can be used in the synthesis of peptides containing histidine and lysine.

Technology Process of Methyl L-lysinate dihydrochloride

There total 18 articles about Methyl L-lysinate dihydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

methanol (67-56-1) + L-Lysine hydrochloride (657-27-2,10098-89-2,26124-78-7) → lysine methyl ester dihydrochloride (13515-95-2,15445-34-8,26348-70-9,34015-48-0,67396-08-1,130336-19-5)

Guidance literature:

With thionyl chloride; for 17h; Reflux;

DOI:10.1016/j.tetlet.2015.12.070

Reference yield: 100.0%

methanol (67-56-1) + L-lysine (56-87-1,3506-25-0) → lysine methyl ester dihydrochloride (13515-95-2,15445-34-8,26348-70-9,34015-48-0,67396-08-1,130336-19-5)

Guidance literature:

methanol; With thionyl chloride; at 0 ℃; for 0.166667h;

L-lysine; at 0 ℃; for 3.16667h; Reflux;

DOI:10.1016/j.tet.2016.04.084

Reference yield: 99.4%

chloro-trimethyl-silane (75-77-4) + L-Lysine hydrochloride (657-27-2,10098-89-2,26124-78-7) → lysine methyl ester dihydrochloride (13515-95-2,15445-34-8,26348-70-9,34015-48-0,67396-08-1,130336-19-5)

Guidance literature:

In methanol;

upstream raw materials:

methanol

L-lysine

L-Lysine hydrochloride

2,2-dimethoxy-propane

Downstream raw materials:

N₂,N₆-dibenzylidene-D,L-lysine methyl ester

Methyl N,N'-α,ε-bis(N-tert-butyloxycarbonyl-2-phenylthiazolidine-4-carbonyl)-L-lysine

2-aminocaprolactam

methyl 6-amino-2-[2-(2,3-dimethylphenylamino)benzamido]hexanoate

Refernces

• 1、 Pandya, Anjali,Patravale, Vandana,Pukale, Sudeep. "Synthesis, characterization and topical application of novel bifunctional peptide metallodendrimer". . . Retrieved 2021/10/30.
• 2、 Yan, Jijun,Kang, Chuanqing,Bian, Zheng,Jin, Rizhe,Ma, Xiaoye,Gao, Lianxun. "Supramolecular self-assembly of chiral polyimides driven by repeat units and end groups". supporting information. p. 14723 - 14729. Retrieved 2017/11/28.