Methyl 2,6-dimethoxyisonicotinate

Base Information

Chemical Name:Methyl 2,6-dimethoxyisonicotinate
CAS No.:52606-00-5
Molecular Formula:C9H11NO4
Molecular Weight:197.191
Hs Code.:2933399090
NSC Number:152218
DSSTox Substance ID:DTXSID80302630
Wikidata:Q82047502
ChEMBL ID:CHEMBL1304842
Mol file:52606-00-5.mol

Synonyms:Methyl 2,6-dimethoxyisonicotinate;52606-00-5;methyl 2,6-dimethoxypyridine-4-carboxylate;4-Pyridinecarboxylic acid, 2,6-dimethoxy-, methyl ester;MLS000861269;NSC 152218;SMR000460053;HMS2782M20;Maybridge3_004939;2,6-dimethoxy-4-pyridinecarboxylic acid methyl ester;cid_289868;CHEMBL1304842;BDBM73807;DTXSID80302630;HMS1445A11;AMY30395;CCG-45206;MFCD04111112;NSC152218;AKOS030229238;NSC-152218;IDI1_016326;2,6-dimethoxyisonicotinic acid methyl ester;CS-0195629;F20122;SR-01000634989-1

Suppliers and Price of Methyl 2,6-dimethoxyisonicotinate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Methyl2,6-dimethoxypyridine-4-carboxylate
5g
$ 60.00

Matrix Scientific
Methyl 2,6-dimethoxyisonicotinate 95%
10g
$ 2365.00

Matrix Scientific
Methyl 2,6-dimethoxyisonicotinate 95%
5g
$ 1595.00

AOBChem
Methyl2,6-dimethoxypyridine-4-carboxylate 97%
10g
$ 1560.00

Total 8 raw suppliers

Chemical Property of Methyl 2,6-dimethoxyisonicotinate

Chemical Property:

Vapor Pressure:0.00649mmHg at 25°C
Boiling Point:271.3°Cat760mmHg
Flash Point:117.9°C
PSA：57.65000
Density:1.169g/cm³
LogP:0.88540
XLogP3:1.3
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:4
Exact Mass:197.06880783
Heavy Atom Count:14
Complexity:185

Purity/Quality:

HPLC≥98% ^*data from raw suppliers

Methyl2,6-dimethoxypyridine-4-carboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC1=CC(=CC(=N1)OC)C(=O)OC

Technology Process of Methyl 2,6-dimethoxyisonicotinate

There total 2 articles about Methyl 2,6-dimethoxyisonicotinate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: methyl N-benzyl-2-methyl-5-formylpyrrole-3-carboxylate

: 3378-71-0
2,5-dimethylpyrrolide

: 110-86-1
pyridine

: 636-41-9
2-methyl-1H-pyrrole

: 109-06-8
α-picoline

: 462-08-8
pyridin-3-ylamine

: 625-84-3
2,5-Dimethylpyrrole

: 93-58-3,5705-52-2,80226-58-0
benzoic acid methyl ester

: 64-18-6
formic acid

: 1450-72-2
5-methyl-2-hydroxyacetophenone

: 504-60-9,17410-45-6,25212-15-1,64940-84-7
penta-1,3-diene

: 79-20-9
acetic acid methyl ester

: 1193-59-5
1,5-dimethyl-1H-pyrrole-2-carbaldehyde

: 52606-00-5
methyl 2,6-dimethoxyisonicotinate

: 95-13-6
1-indene

Guidance literature:: at 300 - 900 ℃; Inert atmosphere; Pyrolysis;
DOI:10.1002/jhet.3626

Reference yield:

: 5398-44-7
2,6-dichloropyridine-4-carboxylic acid

: 52606-00-5
methyl 2,6-dimethoxyisonicotinate

Guidance literature:: Multi-step reaction with 2 steps

1: sulfuric acid / 1 h / Reflux

2: N,N-dimethyl-formamide / 12 h / Reflux

With sulfuric acid; In N,N-dimethyl-formamide;
DOI:10.1039/c5cc01261a

Reference yield:

: 52606-00-5
methyl 2,6-dimethoxyisonicotinate

: C₅₃H₅₂BF₂I₂N₇O₇

Guidance literature:: Multi-step reaction with 3 steps

1: sodium tetrahydroborate / 1,4-dioxane / 1 h / Reflux

2: manganese(IV) oxide / chloroform / 12 h / 20 °C

3: piperidine; acetic acid / benzene / Reflux; Dean-Stark

With piperidine; manganese(IV) oxide; sodium tetrahydroborate; acetic acid; In 1,4-dioxane; chloroform; benzene;
DOI:10.1039/c5cc01261a