2,6-bis(4-methoxyphenyl)-4-phenylpyridine

Base Information

• Chemical Name: 2,6-bis(4-methoxyphenyl)-4-phenylpyridine
• CAS No.: 50553-98-5
• Molecular Formula: C25H21NO2
• Molecular Weight: 367.447
• Mol file: 50553-98-5.mol

Synonyms:

Chemical Property of 2,6-bis(4-methoxyphenyl)-4-phenylpyridine

Chemical Property:

• Vapor Pressure: 3.13E-10mmHg at 25°C
• Boiling Point: 515.7°Cat760mmHg
• Flash Point: 182.4°C
• Density: 1.125g/cm³

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2,6-bis(4-methoxyphenyl)-4-phenylpyridine

There total 32 articles about 2,6-bis(4-methoxyphenyl)-4-phenylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

benzyl bromide (100-39-0) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 2,6‐bis(4‐methoxyphenyl)‐4‐phenylpyridine (50553-98-5)

Guidance literature:

With ammonium acetate; In neat (no solvent); at 150 ℃; for 8h;

DOI:10.1055/s-0035-1560365

Reference yield: 94.0%

phenylacetic acid (103-82-2) + 1-(4-methoxyphenyl)ethanone O-acetyl oxime (96155-57-6) → 2,6‐bis(4‐methoxyphenyl)‐4‐phenylpyridine (50553-98-5)

Guidance literature:

With oxygen; sodium hydrogensulfite; copper(l) chloride; In N,N-dimethyl-formamide; at 150 ℃;

DOI:10.1039/d1nj01987b

Reference yield: 93.0%

benzaldehyde (100-52-7) + 1-(4-methoxyphenyl)ethanone (100-06-1) → 2,6‐bis(4‐methoxyphenyl)‐4‐phenylpyridine (50553-98-5)

Guidance literature:

With melamine-N₂,N₄,N₆-trisulfonic acid; ammonium acetate; at 120 ℃; for 0.166667h;

upstream raw materials:

2-nitropropane

benzaldehyde

1-(4-methoxyphenyl)ethanone

1-(4-fluorophenyl)ethan-1-one-O-acetyl oxime

Refernces

• 1、 Mouradzadegun,Mostafavi,Ganjali. "A Facile and Green Synthesis of 2,4,6-Triarylpyridine Derivatives Using the Modified Mesoporous Organic Polymer Based on Calix [4]Resorcinarene: As an Efficient and Reusable Heterogeneous Acidic Catalyst". . p. 187 - 195. Retrieved 2019.
• 2、 Bai, Chaolumen,Guo, Huifang,Liu, Xin,Liu, Dan,Sun, Zhaorigetu,Bao, Agula,Baiyin, Menghe,Muschin, Tegshi,Bao, Yong-Sheng. "Pyridine Skeleton Synthesis Using Acetonitrile as C4N1 Units and Solvent". . p. 12664 - 12675. Retrieved 2021/09/18.
• 3、 Wang, Hongshe,Zhao, Weixing,Du, Juan,Wei, Fenyan,Chen, Qi,Wang, Xiaomei. "An efficient one pot three-component synthesis of 2,4,6-triarylpyridines using triflimide as a metal-free catalyst under solvent-free conditions". . p. 5158 - 5163. Retrieved 2019/02/27.