4-Ethoxy-2-hydroxybenzaldehyde

Base Information

• Chemical Name: 4-Ethoxy-2-hydroxybenzaldehyde
• CAS No.: 43057-77-8
• Molecular Formula: C9H10O3
• Molecular Weight: 166.177
• Hs Code.: 2912499000
• European Community (EC) Number: 837-371-0
• DSSTox Substance ID: DTXSID50368480
• Wikidata: Q82155043
• ChEMBL ID: CHEMBL3787035
• Mol file: 43057-77-8.mol

Synonyms:4-ethoxy-2-hydroxybenzaldehyde;43057-77-8;4-Ethoxy-2-hydroxy-benzaldehyde;4-Ethoxysalicylaldehyde;Benzaldehyde, 4-ethoxy-2-hydroxy-;MFCD03032734;4-Ethoxysalicylaldehyd;SCHEMBL1004413;2-hydroxy-4-ethoxy benzaldehyde;CHEMBL3787035;DTXSID50368480;YQHAGJMEOJLAJT-UHFFFAOYSA-N;STK018456;AKOS000115387;AS-30078;SY026476;4-ethoxy-2-hydroxy-benzaldehyde, AldrichCPR;CS-0132189;FT-0652180;EN300-01037;A826129;Z56862355;4-ethoxy-2-hydroxy-benzaldehyde

Chemical Property of 4-Ethoxy-2-hydroxybenzaldehyde

Chemical Property:

• Vapor Pressure: 0.00167mmHg at 25°C
• Melting Point: 34 °C
• Refractive Index: 1.573
• Boiling Point: 285 °C at 760 mmHg
• PKA: 7.84±0.10(Predicted)
• Flash Point: 114.1 °C
• PSA: 46.53000
• Density: 1.186 g/cm³
• LogP: 1.60340
• Storage Temp.: Inert atmosphere,Room Temperature
• XLogP3: 1.9
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 166.062994177
• Heavy Atom Count: 12
• Complexity: 147

Purity/Quality:

97% ^*data from raw suppliers

4-Ethoxy-2-hydroxy-benzaldehyde ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC1=CC(=C(C=C1)C=O)O

Technology Process of 4-Ethoxy-2-hydroxybenzaldehyde

There total 4 articles about 4-Ethoxy-2-hydroxybenzaldehyde which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl bromide (74-96-4) + 2,4-Dihydroxybenzaldehyde (95-01-2) → 4-ethoxy-2-hydroxy-benzaldehyde (43057-77-8)

Guidance literature:

With potassium carbonate; In acetone; Reflux;

Reference yield: 69.0%

4-ethoxybenzaldehyde (10031-82-0) → 4-ethoxy-2-hydroxy-benzaldehyde (43057-77-8)

Guidance literature:

With [ruthenium(II)(η⁶-1-methyl-4-isopropyl-benzene)(chloride)(μ-chloride)]₂; bis-[(trifluoroacetoxy)iodo]benzene; In 1,2-dichloro-ethane; at 100 ℃; for 8h; chemoselective reaction; Schlenk technique; Inert atmosphere;

DOI:10.1002/anie.201405647

Reference yield: 47.0%

ethyl iodide (75-03-6) + 2,4-Dihydroxybenzaldehyde (95-01-2) → 4-ethoxy-2-hydroxy-benzaldehyde (43057-77-8)

Guidance literature:

With potassium hydroxide; In ethanol; at 60 ℃; for 1h;

DOI:10.1021/ja993351q

upstream raw materials:

ethyl iodide

2,4-Dihydroxybenzaldehyde

ethyl bromide

4-ethoxybenzaldehyde

Downstream raw materials:

(2-hydroxy)-p-ethoxybenzylidene-p'-butylaniline

6-ethoxy-2-nitro-benzofuran

5-Ethoxy-2-{[(E)-4-pentyl-phenylimino]-methyl}-phenol

2-{[(E)-4-Butoxy-phenylimino]-methyl}-5-ethoxy-phenol