2-(4-Methoxyphenyl)-1-phenyl-2-(phenylamino)ethanone

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)-1-phenyl-2-(phenylamino)ethanone
• CAS No.: 6338-31-4
• Molecular Formula: C21H19NO2
• Molecular Weight: 317.387
• NSC Number: 40424
• DSSTox Substance ID: DTXSID30285085
• Nikkaji Number: J2.440.306H
• Mol file: 6338-31-4.mol

Synonyms:6338-31-4;2-anilino-2-(4-methoxyphenyl)-1-phenylethanone;2-(4-methoxyphenyl)-1-phenyl-2-(phenylamino)ethanone;NSC40424;DTXSID30285085;NSC-40424

Chemical Property of 2-(4-Methoxyphenyl)-1-phenyl-2-(phenylamino)ethanone

Chemical Property:

• Vapor Pressure: 1.47E-10mmHg at 25°C
• Boiling Point: 511.1°Cat760mmHg
• Flash Point: 262.9°C
• Density: 1.174g/cm³
• XLogP3: 5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 6
• Exact Mass: 317.141578849
• Heavy Atom Count: 24
• Complexity: 377

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C(C(=O)C2=CC=CC=C2)NC3=CC=CC=C3

Technology Process of 2-(4-Methoxyphenyl)-1-phenyl-2-(phenylamino)ethanone

There total 11 articles about 2-(4-Methoxyphenyl)-1-phenyl-2-(phenylamino)ethanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

4-methoxy-benzaldehyde (123-11-5) + aniline (62-53-3) + acetophenone (98-86-2) → 2-(4-methoxyphenyl)-1-phenyl-2-(phenylamino)ethan-1-one (6338-31-4)

Guidance literature:

With cellulose sulfuric acid; In ethanol; at 20 ℃; for 16h;

DOI:10.1080/00397911.2010.520101

Reference yield: 67.0%

benzaldehyde (100-52-7) + N-(4-methoxybenzylidene)aniline (1613-96-3) → 2-(4-methoxyphenyl)-1-phenyl-2-(phenylamino)ethan-1-one (6338-31-4)

Guidance literature:

With triethylamine; 3-benzyl-5-(2-hydroxyethyl)-4-methyl-1,3-thiazol-3-ium chloride; In ethanol; at 70 ℃; for 48h;

DOI:10.1039/b611646a

Reference yield: 61.0%

C27H32N2O3Ti → 2-(4-methoxyphenyl)-1-phenyl-2-(phenylamino)ethan-1-one (6338-31-4)

Guidance literature:

With hydrogenchloride; water; at 20 ℃; for 0.5h; Schlenk technique; Inert atmosphere;

DOI:10.1016/j.tetlet.2014.01.070

upstream raw materials:

4-methoxybenzoin

aniline

2-hydroxy-2-phenylacetophenone

N-(4-methoxybenzylidene)aniline

Downstream raw materials:

α-anilino-4-methoxy-deoxybenzoin

3-(4-methoxyphenyl)-2-phenyl-1H-indole