10-ethyl-10H-phenothiazine

Base Information

• Chemical Name: 10-ethyl-10H-phenothiazine
• CAS No.: 1637-16-7
• Molecular Formula: C14H13 N S
• Molecular Weight: 227.33
• Hs Code.: 2934300000
• Mol file: 1637-16-7.mol

Synonyms:Phenothiazine,10-ethyl- (6CI,7CI,8CI); 10-Ethylphenothiazine; N-Ethylphenothiazine; NSC 121

Chemical Property of 10-ethyl-10H-phenothiazine

Chemical Property:

• Vapor Pressure: 3.18E-05mmHg at 25°C
• Melting Point: 102.5-103.0 °C
• Boiling Point: 355.2°Cat760mmHg
• PKA: 0.83±0.20(Predicted)
• Flash Point: 168.6°C
• PSA: 28.54000
• Density: 1.17g/cm³
• LogP: 4.37420

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

Technology Process of 10-ethyl-10H-phenothiazine

There total 19 articles about 10-ethyl-10H-phenothiazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

ethyl bromide (74-96-4) + 10H-phenothiazine (92-84-2) → 10-ethyl-phenothiazine (1637-16-7)

Guidance literature:

10H-phenothiazine; With sodium hydride; In tetrahydrofuran; mineral oil; at 0 ℃; for 1h; Inert atmosphere;

ethyl bromide; In tetrahydrofuran; mineral oil; at 20 ℃; for 12.5h; Inert atmosphere;

DOI:10.1016/j.ica.2016.03.042

Reference yield: 95.0%

10H-phenothiazine (92-84-2) + ethyl iodide (75-03-6) → 10-ethyl-phenothiazine (1637-16-7)

Guidance literature:

With sodium amide; at 72 - 73 ℃; for 8h;

DOI:10.1515/HC.2001.7.3.277

Reference yield: 80.0%

10H-phenothiazine (92-84-2) + diethyl chlorophosphate (814-49-3) → 10-ethyl-phenothiazine (1637-16-7)

Guidance literature:

With potassium carbonate; at 100 ℃; for 1h; Microwave irradiation;

DOI:10.1080/10426507.2012.668986

upstream raw materials:

ethyl bromide

10H-phenothiazine

2-ethanesulfonylmethyl-5-bromo-thiophene

N-ethyl-2-(2-nitro-phenylsulfanyl)-aniline

Downstream raw materials:

(10-ethyl-10H-phenothiazin-4-yl)-phenyl-methanone

10-ethyl-10H-phenothiazine-3-carbaldehyde

10-ethylphenothiazine radical cation

N-ethylcarbazole

Refernces

• 1、 Zhang, Tong,Han, Yanning,Liang, Meng,Bian, Weixiao,Zhang, Yan,Li, Xiaoting,Zhang, Chunyu,Xue, Pengchong. "Substituent effect on photophysical properties, crystal structures and mechanochromism of D-π-A phenothiazine derivatives". . . Retrieved 2019.
• 2、 Hua, Yong,Chang, Shuai,Huang, Dandan,Zhou, Xuan,Zhu, Xunjin,Zhao, Jianzhang,Chen, Tao,Wong, Wai-Yeung,Wong, Wai-Kwok. "Significant improvement of dye-sensitized solar cell performance using simple phenothiazine-based dyes". . p. 2146 - 2153. Retrieved 2013.
• 3、 Brem, Juergen,Pilbak, Sarolta,Paizs, Csaba,Banoczi, Gergely,Irimie, Florin-Dan,Tosa, Monica-Ioana,Poppe, Laszlo. "Lipase-catalyzed kinetic resolutions of racemic 1-(10-ethyl-10H- phenothiazin-1,2, and 4-yl)ethanols and their acetates". . p. 916 - 923. Retrieved 2011.
• 4、 Iqbal, Zafar,Wu, Wu-Qiang,Zhang, Hai,Hua, Peng-Li,Fang, Xiaoming,Kuang, Dai-Bin,Wang, Lingyun,Meier, Herbert,Cao, Derong. "Impact of hydroxy and octyloxy substituents of phenothiazine based dyes on the photovoltaic performance". . p. 299 - 307. Retrieved 2013.
• 5、 Zhang, Tong,Han, Yanning,Chen, Qiao,Chen, Xinyu,Xue, Pengchong. "Electric and steric hindrance effects of substituents on luminescence and force-stimuli response of cyanovinyl phenothiazine derivatives". . . Retrieved 2021.
• 6、 Xie, Feng-Ming,Ou, Qingdong,Zhang, Qiang,Zhang, Jiang-Kun,Dai, Guo-Liang,Zhao, Xin,Wei, Huai-Xin. "Two novel blue phosphorescent host materials containing phenothiazine-5,5-dioxide structure derivatives". . p. 869 - 874. Retrieved 2018.
• 7、 Li, Hongfang,Miao, Yu,Liu, Zhixue,Wu, Xue,Piao, Chunxiang,Zhou, Xin. "A mitochondria-targeted fluorescent probe for fast detecting hypochlorite in living cells". . . Retrieved 2020.
• 8、 Zhou, Yan-Tao,Cai, Zhi-Bin,Pan, Yu-Lu,Bai, Li,Zheng, Guo-Chuang,Li, Sheng-Li,Tian, Yu-Peng. "Synthesis, optical characterization, and solvatochromism study of new two-photon absorption compounds". . p. 2271 - 2279. Retrieved 2016.
• 9、 Collini, Melissa A.,Thomas, Michael B.,Bandi, Venugopal,Karr, Paul A.,D'Souza, Francis. "Directly Attached Bisdonor-BF2 Chelated Azadipyrromethene-Fullerene Tetrads for Promoting Ground and Excited State Charge Transfer". . p. 4450 - 4461. Retrieved 2017.
• 10、 Chao, Wei-Chih,Chiang, Tzu-Hsuan,Chaudhari, Prakash D.,Lin, Li-Ju,Lu, Jyh-Feng,Hong, Bor-Cherng,Wang, Jinn-Shyan,Lin, Ta-Chun,Shen, Jiun-Yi,Chou, Pi-Tai. "The azatryptophan-based fluorescent platform for in vitro rapid screening of inhibitors disrupting IKKβ-NEMO interaction". . p. 504 - 511. Retrieved 2018.