1-Methyl-3-hydroxy-2(1H)-pyridinone

Base Information

• Chemical Name: 1-Methyl-3-hydroxy-2(1H)-pyridinone
• CAS No.: 19365-01-6
• Molecular Formula: C₆H₇NO₂
• Molecular Weight: 125.127
• Hs Code.: 2933399090
• European Community (EC) Number: 864-449-1
• DSSTox Substance ID: DTXSID00172973
• Nikkaji Number: J323.391J
• Wikidata: Q83043065
• ChEMBL ID: CHEMBL52209
• Mol file: 19365-01-6.mol

Synonyms:1-methyl-3-hydroxypyrid-2-one;1-methyl-3-hydroxypyridine-2-one;1-MHPO

Chemical Property of 1-Methyl-3-hydroxy-2(1H)-pyridinone

Chemical Property:

• Vapor Pressure: 4.95E-05mmHg at 25°C
• Melting Point: 126-127 °C(Solv: ligroine (8032-32-4))
• Boiling Point: 311.6°C at 760 mmHg
• PKA: 9.03±0.58(Predicted)
• Flash Point: 142.2°C
• PSA: 42.23000
• Density: 1.309g/cm³
• LogP: 0.09090
• Storage Temp.: Sealed in dry,Room Temperature
• XLogP3: 0.2
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 0
• Exact Mass: 125.047678466
• Heavy Atom Count: 9
• Complexity: 193

Purity/Quality:

97% ^*data from raw suppliers

1-methyl-3-hydroxy-2(1H)-pyridinone 98 ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CN1C=CC=C(C1=O)O

Technology Process of 1-Methyl-3-hydroxy-2(1H)-pyridinone

There total 11 articles about 1-Methyl-3-hydroxy-2(1H)-pyridinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 93.0%

3-(benzyloxy)-1-methylpyridin-2(1H)-one (94475-65-7) → 1-methyl-3-hydroxy-2(1H)-pyridinone (19365-01-6)

Guidance literature:

With palladium on activated charcoal; hydrogen; In methanol; at 20 ℃; for 16h; under 775.743 Torr;

Reference yield: 72.0%

3-methoxy-1-methyl-2(1H)-pyridone (54955-13-4) → 1-methyl-3-hydroxy-2(1H)-pyridinone (19365-01-6)

Guidance literature:

With boron tribromide; In dichloromethane; at -30 - 20 ℃; for 48h; Inert atmosphere;

DOI:10.1021/jm301769u

Reference yield: 62.6%

3-Hydroxy-2(1H)-pyridinone (84719-32-4) + methyl iodide (74-88-4) → 1-methyl-3-hydroxy-2(1H)-pyridinone (19365-01-6)

Guidance literature:

3-Hydroxy-2(1H)-pyridinone; methyl iodide; at 150 ℃; for 48 - 60h;

With sodium sulfite; In water;

upstream raw materials:

2-methoxy-3-hydroxypyridine

methyl iodide

dihydroxypyridine

3-(benzyloxy)-1-methylpyridin-2(1H)-one

Downstream raw materials:

3-hydroxy-1-methyl-2-piperidinone

3-benzyloxy-4-carboxy-1-methyl-2(1H)-pyridinone

1-Methyl-3-(phenyl-hydrazono)-piperidin-2-one

3-hydroxy-1-methylpyridine-2(1H)-thione

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