4-Cyclooctylpyridine

Base Information

• Chemical Name: 4-Cyclooctylpyridine
• CAS No.: 106754-33-0
• Molecular Formula: C13H19N
• Molecular Weight: 189.301
• DSSTox Substance ID: DTXSID70565494
• Wikidata: Q82450621
• Mol file: 106754-33-0.mol

Synonyms:4-Cyclooctylpyridine;106754-33-0;DTXSID70565494

Chemical Property of 4-Cyclooctylpyridine

Chemical Property:

• XLogP3: 4.5
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 189.151749610
• Heavy Atom Count: 14
• Complexity: 141

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1CCCC(CCC1)C2=CC=NC=C2

Technology Process of 4-Cyclooctylpyridine

There total 10 articles about 4-Cyclooctylpyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 35.0%

pyridine-4-carbonitrile (100-48-1) + Cyclooctan (292-64-8) → diphenyl(pyridin-4-yl)methanol (1620-30-0) + 4-cyclooctyl-pyridine (106754-33-0)

Guidance literature:

With benzophenone; In water; acetonitrile; at 20 ℃; for 22h; chemoselective reaction; Irradiation;

DOI:10.1039/c3sc51080h

Reference yield:

2-Picolinic acid (98-98-6) + tert.-butylhydroperoxide (75-91-2) + Cyclooctan (292-64-8) → cis-Cyclooctene (931-88-4,931-87-3,25267-51-0) + cycloactanone (502-49-8) + 4-cyclooctyl-pyridine (106754-33-0) + cyclooctyl-tert-butyl peroxide (145175-64-0) + 2-cyclooctyl-pyridine

Guidance literature:

ferric nitrate; In pyridine; acetic acid; at 50 ℃; for 12h; Product distribution; Mechanism;

DOI:10.1016/S0040-4039(00)61120-6

Reference yield:

pyridine (110-86-1) + Cyclooctan (292-64-8) → cyclohexyl chloride (542-18-7) + 4-cyclooctyl-pyridine (106754-33-0) + cyclooctyl-tert-butyl peroxide (145175-64-0) + 2-cyclooctyl-pyridine

Guidance literature:

With tert.-butylhydroperoxide; lithium chloride; ferric nitrate; In acetic acid; at 60 ℃; for 4.5h;

DOI:10.1016/S0040-4020(01)80735-3

upstream raw materials:

pyridine

tert.-butylhydroperoxide

Cyclooctan

2-Picolinic acid