4-Phenyl-2-(4-pyridyl)thiazole

Base Information

• Chemical Name: 4-Phenyl-2-(4-pyridyl)thiazole
• CAS No.: 106950-18-9
• Molecular Formula: C14H10N2S
• Molecular Weight: 238.313
• Hs Code.: 2934100090
• European Community (EC) Number: 681-283-3
• DSSTox Substance ID: DTXSID40353340
• Wikidata: Q82130865
• ChEMBL ID: CHEMBL1416100
• Mol file: 106950-18-9.mol

Synonyms:4-phenyl-2-(4-pyridyl)thiazole;106950-18-9;4-phenyl-2-pyridin-4-yl-1,3-thiazole;MLS000707354;SMR000288819;4-Phenyl-2-(4-pyridyl)thiazole, 97per cent;BAS 03014745;Maybridge1_005309;Oprea1_416910;cid_738483;CHEMBL1416100;SCHEMBL13480645;BDBM93830;4-phenyl-2-pyridin-4-ylthiazole;DTXSID40353340;HMS2755F06;MFCD02366451;AKOS000563426;SB55236;ML 00033;4-(4-phenyl-1,3-thiazol-2-yl)pyridine;4-Phenyl-2-(4-pyridyl)thiazole, AldrichCPR;MLS-0279314.0001;MLS-0279314.0002;EN300-13923163;Z238746874

Chemical Property of 4-Phenyl-2-(4-pyridyl)thiazole

Chemical Property:

• Melting Point: 91-95℃
• PSA: 54.02000
• LogP: 3.87210
• XLogP3: 3.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 238.05646950
• Heavy Atom Count: 17
• Complexity: 234

Purity/Quality:

97% ^*data from raw suppliers

4-Phenyl-2-(4-pyridyl)thiazole 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C(C=C1)C2=CSC(=N2)C3=CC=NC=C3

Technology Process of 4-Phenyl-2-(4-pyridyl)thiazole

There total 4 articles about 4-Phenyl-2-(4-pyridyl)thiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

pyridine-4-carbothioamide (2196-13-6) + α-bromoacetophenone (70-11-1) → 4-phenyl-2-(pyridin-4-yl)thiazole (106950-18-9)

Guidance literature:

In ethanol; at 25 ℃; for 17h; Reflux;

DOI:10.1021/acs.orglett.9b04545

Reference yield: 65.0%

pyridine-4-carbothioamide (2196-13-6) + 1-phenyl-2-(p-tolylsulfonyloxy)ethanone (7257-94-5) → 4-phenyl-2-(pyridin-4-yl)thiazole (106950-18-9)

Guidance literature:

In water; at 60 ℃; for 5h;

DOI:10.1016/j.tetlet.2011.02.069

Reference yield: 47.0%

4-(aminomethyl)pyridine (3731-53-1) + acetophenone (98-86-2) → 4-phenyl-2-(pyridin-4-yl)thiazole (106950-18-9)

Guidance literature:

With pyridine-4-carboxylic acid; sulfur; In dimethyl sulfoxide; at 130 ℃; for 8h;

DOI:10.1039/c9ra09656f

upstream raw materials:

pyridine-4-carbothioamide

α-bromoacetophenone

1-phenyl-2-(p-tolylsulfonyloxy)ethanone

4-(aminomethyl)pyridine