2-Bromo-1-methoxy-4-(methoxymethyl)benzene

Base Information

• Chemical Name: 2-Bromo-1-methoxy-4-(methoxymethyl)benzene
• CAS No.: 111210-24-3
• Molecular Formula: C9H11BrO2
• Molecular Weight: 231.089
• DSSTox Substance ID: DTXSID00552998
• Mol file: 111210-24-3.mol

Synonyms:2-Bromo-1-methoxy-4-(methoxymethyl)benzene;111210-24-3;SCHEMBL4696875;DTXSID00552998;QUZGPFANEYVMBN-UHFFFAOYSA-N;MFCD14686970;AKOS010793498;2-bromo-1-methoxy-4-methoxymethyl-benzene;CS-0194701;E90950;EN300-207244;A1-05213

Chemical Property of 2-Bromo-1-methoxy-4-(methoxymethyl)benzene

Chemical Property:

• PSA: 18.46000
• LogP: 2.60410
• XLogP3: 2.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 3
• Exact Mass: 229.99424
• Heavy Atom Count: 12
• Complexity: 130

Purity/Quality:

97% ^*data from raw suppliers

2-Bromo-1-methoxy-4-(methoxymethyl)benzene ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COCC1=CC(=C(C=C1)OC)Br

Technology Process of 2-Bromo-1-methoxy-4-(methoxymethyl)benzene

There total 2 articles about 2-Bromo-1-methoxy-4-(methoxymethyl)benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

(3-bromo-4-methoxy-phenyl)-methanol (38493-59-3) + methyl iodide (74-88-4) → 2-bromo-1-methoxy-4-(methoxymethyl)benzene (111210-24-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide; mineral oil; at 0 - 20 ℃; for 0.5h;

Reference yield:

2-bromo-4-(bromomethyl)-1-methoxybenzene (89978-72-3) + sodium methylate (124-41-4) → 2-bromo-1-methoxy-4-(methoxymethyl)benzene (111210-24-3)

Guidance literature:

In methanol; benzene; for 2h; Yield given; Heating;

DOI:10.1021/jo00292a017

Reference yield: 84.0%

methanol (67-56-1) + carbon monoxide (201230-82-2) + 2-bromo-1-methoxy-4-(methoxymethyl)benzene (111210-24-3) → methyl 2-methoxy-5-(methoxymethyl)benzoate (91971-22-1)

Guidance literature:

With dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; triethylamine; In dichloromethane; at 100 ℃;

upstream raw materials:

2-bromo-4-(bromomethyl)-1-methoxybenzene

sodium methylate

(3-bromo-4-methoxy-phenyl)-methanol

methyl iodide

Downstream raw materials:

2-Amino-4-methoxybenzyl methyl ether

2-(5-Methoxy-2-methoxymethyl-phenyl)-butyronitrile

2-(2-Methoxy-5-methoxymethyl-phenyl)-butyronitrile

2-cyano-3-(2'-fluorobenzyl)-4-(methoxymethyl)anisole