1-Methyl-3-phenylimidazol-2-one

Base Information

• Chemical Name: 1-Methyl-3-phenylimidazol-2-one
• CAS No.: 1201-15-6
• Molecular Formula: C10H10N2O
• Molecular Weight: 174.202
• DSSTox Substance ID: DTXSID301242785
• Nikkaji Number: J2.153.484F
• Mol file: 1201-15-6.mol

Synonyms:1-methyl-3-phenylimidazol-2-one;1201-15-6;SCHEMBL7133435;SDXZEGKIWVOOFU-UHFFFAOYSA-N;DTXSID301242785;AKOS004090669;1,3-Dihydro-1-methyl-3-phenyl-2H-imidazol-2-one

Chemical Property of 1-Methyl-3-phenylimidazol-2-one

Chemical Property:

• XLogP3: 1.1
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 1
• Exact Mass: 174.079312947
• Heavy Atom Count: 13
• Complexity: 231

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

• Canonical SMILES: CN1C=CN(C1=O)C2=CC=CC=C2

Technology Process of 1-Methyl-3-phenylimidazol-2-one

There total 10 articles about 1-Methyl-3-phenylimidazol-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

1-phenyl-1,3-dihydro-2H-imidazol-2-one (53995-06-5) + methyl iodide (74-88-4) → 3-methyl-1-phenylimidazol-2(1H)-one (1201-15-6)

Guidance literature:

1-phenyl-1,3-dihydro-2H-imidazol-2-one; With n-butyllithium; In tetrahydrofuran; at -78 - 0 ℃;

methyl iodide; In tetrahydrofuran; at -78 - 20 ℃;

DOI:10.1139/v04-137

Reference yield: 90.8%

1-methyl-1-(2,2-dimethoxyethyl)-3-phenylurea (928729-62-8) → 3-methyl-1-phenylimidazol-2(1H)-one (1201-15-6)

Guidance literature:

With trifluoroacetic acid; In chloroform; at 60 ℃; for 4h;

DOI:10.1016/j.mencom.2008.01.020

Reference yield: 24.0%

N-phenyl-1H-imidazole-1-carboxamide (33876-94-7) + methylamine (74-89-5) → 3-methyl-1-phenylimidazol-2(1H)-one (1201-15-6)

Guidance literature:

methylamine; bromoacetal LCC-Dynosphere polystyrene resin; In 1-methyl-pyrrolidin-2-one; dimethyl sulfoxide; at 80 ℃;

N-phenyl-1H-imidazole-1-carboxamide; In 1-methyl-pyrrolidin-2-one; at 70 ℃;

With trifluoroacetic acid; for 16h;

DOI:10.1055/s-2004-831316

upstream raw materials:

methyl iodide

N-phenyl-1H-imidazole-1-carboxamide

methylamine

phenyl isocyanate

Downstream raw materials:

1-phenyl-3,4-dimethylimidazol-2(1H)-one

4-(3-methyl-2-oxoimidazolidin-1-yl)benzene-1-sulfonyl chloride

5-(2,4-dihydroxy-3-methylphenyl)-1-methyl-3-phenylimidazolidin-2-one

4-(2,3,4-trihydroxy-phenyl)-3-methyl-1-phenylimidazolidin-2-one