5-AMINO-3-(2-PHENOXYETHOXY)-1H-PYRAZOL

Base Information

• Chemical Name: 5-AMINO-3-(2-PHENOXYETHOXY)-1H-PYRAZOL
• CAS No.: 120259-21-4
• Molecular Formula: C11H13N3O2
• Molecular Weight: 219.243
• Mol file: 120259-21-4.mol

Synonyms:

Chemical Property of 5-AMINO-3-(2-PHENOXYETHOXY)-1H-PYRAZOL

Chemical Property:

• PSA: 73.16000
• LogP: 2.03090

Purity/Quality:

1H-Pyrazol-3-amine,5-(2-phenoxyethoxy)- 96% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 5-AMINO-3-(2-PHENOXYETHOXY)-1H-PYRAZOL

There total 2 articles about 5-AMINO-3-(2-PHENOXYETHOXY)-1H-PYRAZOL which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 33.0%

2-Phenoxyethanol (122-99-6,56257-90-0,9004-78-8) + 5-Amino-3-hydroxypyrazole (28491-52-3) → 5-(2-phenoxy-ethoxy)-2H-pyrazol-3-yl-amine (120259-21-4)

Guidance literature:

2-Phenoxyethanol; 5-Amino-3-hydroxypyrazole; With toluene-4-sulfonic acid; at 130 ℃; for 5h; reduced pressure;

With sodium hydrogencarbonate; In water; at 1 - 30 ℃;

Reference yield: 23.0%

2-Phenoxyethanol (122-99-6,56257-90-0,9004-78-8) + Cyanoacetohydrazide (140-87-4) → 5-(2-phenoxy-ethoxy)-2H-pyrazol-3-yl-amine (120259-21-4)

Guidance literature:

2-Phenoxyethanol; Cyanoacetohydrazide; With toluene-4-sulfonic acid; In toluene; for 5h; Heating / reflux;

With sodium hydroxide; In water;

Reference yield: 45.0%

5-(2-phenoxy-ethoxy)-2H-pyrazol-3-yl-amine (120259-21-4) + diethyl malonate (105-53-3) → 5,7-dichloro-2-(2-phenoxy-ethoxy)pyrazole[1,5-a]pyrimidine (1232223-84-5)

Guidance literature:

5-(2-phenoxy-ethoxy)-2H-pyrazol-3-yl-amine; diethyl malonate; With sodium ethanolate; In ethanol; at 150 ℃; for 0.833333h; microwave irradiation;

With trichlorophosphate; for 2h; Cooling with ice; Reflux;

upstream raw materials:

2-Phenoxyethanol

Cyanoacetohydrazide

5-Amino-3-hydroxypyrazole

Downstream raw materials:

5,7-dichloro-2-(2-phenoxy-ethoxy)pyrazole[1,5-a]pyrimidine

5-chloro-7-morpholin-4-yl-2-(2-phenoxy-ethoxy)-pyrazolo[1,5-a]pyrimidine

Refernces

• 1、 -. "Novel Compounds". Page/Page column 104. . Retrieved 2008/06/13.