1-[Morpholin-4-yl(phenyl)methyl]-2-naphthol

Base Information

• Chemical Name: 1-[Morpholin-4-yl(phenyl)methyl]-2-naphthol
• CAS No.: 24685-08-3
• Molecular Formula: C21H21 N O2
• Molecular Weight: 319.403
• Hs Code.: 2934999090
• NSC Number: 79464
• DSSTox Substance ID: DTXSID90291985
• Nikkaji Number: J1.201.302G
• Mol file: 24685-08-3.mol

Synonyms:24685-08-3;1-[morpholin-4-yl(phenyl)methyl]-2-naphthol;NSC79464;Oprea1_602322;CBDivE_006639;SCHEMBL5387426;DTXSID90291985;1260596-62-0;1260616-25-8;NSC-79464;AB06335;AB56367;AB56368;374690-61-6;1-(morpholino-(phenyl)-methyl)-2-naphthol;1-[4-Morpholinyl(phenyl)methyl]-2-naphthol;1-[4-Morpholinyl(phenyl)methyl]-2-naphthol #;2-Naphthalenol, 1-(.alpha.-morpholynobenzyl)-;AB00075016-01;1-(Morpholin-4-yl-phenyl-methyl]-naphthalen-2-ol;Naphthalen-2-ol, 1-(4-morpholyl)(phenyl)methyl-;SR-01000197954;1-(MORPHOLINO(PHENYL)METHYL)NAPHTHALEN-2-OL;SR-01000197954-1;1-((R)-MORPHOLINO(PHENYL)METHYL)NAPHTHALEN-2-OL;1-((S)-MORPHOLINO(PHENYL)METHYL)NAPHTHALEN-2-OL

Chemical Property of 1-[Morpholin-4-yl(phenyl)methyl]-2-naphthol

Chemical Property:

• Vapor Pressure: 6.87E-10mmHg at 25°C
• Boiling Point: 481.3°Cat760mmHg
• Flash Point: 244.9°C
• PSA: 32.70000
• Density: 1.213g/cm³
• LogP: 3.90490
• XLogP3: 4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 319.157228913
• Heavy Atom Count: 24
• Complexity: 389

Purity/Quality:

99%min ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1COCCN1C(C2=CC=CC=C2)C3=C(C=CC4=CC=CC=C43)O

Technology Process of 1-[Morpholin-4-yl(phenyl)methyl]-2-naphthol

There total 8 articles about 1-[Morpholin-4-yl(phenyl)methyl]-2-naphthol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

morpholine (110-91-8,99108-56-2) + benzaldehyde (100-52-7) + β-naphthol (135-19-3) → 1-(phenyl(morpholin-4-yl)methyl)naphthalen-2-ol (24685-08-3)

Guidance literature:

With Amberlite IRA-400 Cl resin; In ethanol; for 3h; Reflux;

DOI:10.1016/j.molstruc.2021.130861

Reference yield: 85.0%

1-morpholino[(phenyl)methyl]benzotriazole (120803-36-3) + sodium 2-naphtholate (875-83-2) → 1-(phenyl(morpholin-4-yl)methyl)naphthalen-2-ol (24685-08-3)

Guidance literature:

With 18-crown-6 ether; In toluene; for 12h; Heating;

DOI:10.1021/jo9903609

Reference yield: 82.0%

morpholine (110-91-8,99108-56-2) + 2-hydroxynaphthalene-1-carbaldehyde (708-06-5) + phenylboronic acid (98-80-6) → 1-(phenyl(morpholin-4-yl)methyl)naphthalen-2-ol (24685-08-3)

Guidance literature:

With CuO nanoparticle decorated reduced graphene oxide composite; In dichloromethane; at 70 ℃; Microwave irradiation; Green chemistry;

DOI:10.1039/c8ra05203d

upstream raw materials:

morpholine

1-(α-aminobenzyl)-2-naphthol

benzaldehyde

β-naphthol

Downstream raw materials:

3,3'-bis-indolyl(phenyl)methane

1-benzyl-2-naphthol

4-[(2-methoxy-naphthalen-1-yl)-phenyl-methyl]-morpholine

Refernces

• 1、 Dennis Raj,Jeeva,Shankar,Venkatesa Prabhu,Vimalan,Vetha Potheher. "Synthesis, growth, physicochemical properties and DFT calculations of 2-naphthol substituted Mannich base 1-(morpholino(phenyl) methyl) naphthalen-2-ol: A non linear optical single crystal". . p. 763 - 775. Retrieved 2017.
• 2、 Akbarpour, Tahereh,Khazaei, Ardeshir,Sarmasti, Negin,Yousefi Seyf, Jaber. "Synthesis of 1-aminoalkyl-2-naphthols derivatives using an engineered copper-based nanomagnetic catalyst (Fe3O4@CQD@Si (OEt)(CH2)3NH@CC@N3@phenylacetylene@Cu)". . . Retrieved 2021/07/26.
• 3、 Goudarziafshar, Hamid,Moosavi-Zare, Ahmad Reza,Hasani, Jafar. "Design and identification of nano-Mg-[4-methoxy phenyl-salicylaldimine–methyl-pyranopyrzole] Cl2 and its catalytic application on the preparation of 1-(α-aminoalkyl)-2-naphthols". . . Retrieved 2020/01/25.