3,3-dimethyl-2,3-dihydro-1-benzofuran

Base Information

• Chemical Name: 3,3-dimethyl-2,3-dihydro-1-benzofuran
• CAS No.: 13524-78-2
• Molecular Formula: C10H12O
• Molecular Weight: 148.205
• Mol file: 13524-78-2.mol

Synonyms:2,3-dihydro-3,3-dimethyl-5-hydroxy-2-morpholinobenzofuran;3,3-dimethyl-2-morpholin-4-yl-2,3-dihydro-benzofuran-5-ol;5-Hydroxy-3,3-dimethyl-2-morpholino-cumaran;3,3-dimethyl-2,3-dihydro-benzofuran;2,3-dihydro-3,3-dimethylbenzofuran;2,3-dihydro-3,3-dimethyl-2-morpholino-5-hydroxybenzofuran;

Chemical Property of 3,3-dimethyl-2,3-dihydro-1-benzofuran

Chemical Property:

• Vapor Pressure: 0.349mmHg at 25°C
• Boiling Point: 206oC at 760 mmHg
• Flash Point: 70.6oC
• PSA: 9.23000
• Density: 1.001g/cm3
• LogP: 2.35660

Purity/Quality:

NLT 98% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 3,3-dimethyl-2,3-dihydro-1-benzofuran

There total 18 articles about 3,3-dimethyl-2,3-dihydro-1-benzofuran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

C30H36N2OPd + bromine (7726-95-6) → 3,3-dimethyl-2,3-dihydrobenzo[b]furan (13524-78-2) + C20H24Br2N2Pd

Guidance literature:

In [⁽²⁾H₆]acetone; for 2h;

DOI:10.1021/acs.organomet.6b00387

Reference yield: 85.0%

C30H36N2OPd + iodine (7553-56-2,12190-71-5,8031-47-8) → 3,3-dimethyl-2,3-dihydrobenzo[b]furan (13524-78-2) + C20H24I2N2Pd

Guidance literature:

In [⁽²⁾H₆]acetone; for 2h;

DOI:10.1021/acs.organomet.6b00387

Reference yield: 83.0%

2-(2-methoxyphenyl)propene (10278-02-1) → 3,3-dimethyl-2,3-dihydrobenzo[b]furan (13524-78-2) + o-isopropylanisole (2944-47-0)

Guidance literature:

With (S)-(+)-5,5’-bis[di(3,5-di-tert-butyl-4-methoxyphenyl)phosphino]-4,4’-bi-1,3-benzodioxole; di-μ-chlorotetrakis(ethene)diiridium(I); In toluene; at 110 ℃; for 60h; Reagent/catalyst; Temperature; Sealed tube; Inert atmosphere;

DOI:10.1002/adsc.201900749

upstream raw materials:

1-bromo-2-((2-methylallyl)oxy)benzene

carbon dioxide

1-chloro-2-((2-methylallyl)oxy)benzene

methyl iodide