Picolinic Acid Hydrochloride

Base Information

• Chemical Name: Picolinic Acid Hydrochloride
• CAS No.: 636-80-6
• Molecular Formula: C6H6ClNO2
• Molecular Weight: 159.572
• Hs Code.: 2933399090
• European Community (EC) Number: 211-266-4
• NSC Number: 363779
• UNII: 8HE8GCH2RD
• DSSTox Substance ID: DTXSID7060912
• Mol file: 636-80-6.mol

Synonyms:Picolinic Acid Hydrochloride;636-80-6;Pyridine-2-carboxylic Acid Hydrochloride;Picolinic acid HCl;2-Pyridinecarboxylic acid, hydrochloride;pyridine-2-carboxylic acid;hydrochloride;alpha-Picolinic acid hydrochloride;2-Pyridinecarboxylic acid, hydrochloride (1:1);EINECS 211-266-4;NSC 363779;NSC-363779;2-pyridinecarboxylic acid hydrochloride;PICOLINICACIDHYDROCHLORIDE;8HE8GCH2RD;SCHEMBL1469;picolinic acid, hydrochloride;2-picolinic acid hydrochloride;DTXSID7060912;alpha -Picolinic Acid Hydrochloride;CK2602;MFCD00050666;NSC363779;AKOS015849464;AS-45929;CS-0063155;P0422;PYRIDINE-2-CARBOXYLIC ACID, HYDROCHLORIDE;A868065;F0001-1727

Chemical Property of Picolinic Acid Hydrochloride

Chemical Property:

• Vapor Pressure: 0.000836mmHg at 25°C
• Melting Point: 229 °C(Solv: ethanol (64-17-5))
• Boiling Point: 292.5 °C at 760 mmHg
• Flash Point: 130.7 °C
• PSA: 50.19000
• LogP: 1.58180
• Storage Temp.: Inert atmosphere,Room Temperature
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 159.0087061
• Heavy Atom Count: 10
• Complexity: 114

Purity/Quality:

98%,99%, ^*data from raw suppliers

PicolinicAcid ^*data from reagent suppliers

Safty Information:

• Statements: 36/37/38
• Safety Statements: 26-36/37/39

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=NC(=C1)C(=O)O.Cl

Technology Process of Picolinic Acid Hydrochloride

There total 4 articles about Picolinic Acid Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

pyridine-2-carbaldehyde (1121-60-4) → 2-picolinic acid hydrochloride (636-80-6)

Guidance literature:

pyridine-2-carbaldehyde; With 9-oxyl-9-azabicyclo<3.3.1>nonan-3-one; oxygen; nitric acid; sodium nitrite; In water; acetonitrile; at 23 ℃; for 8h; under 760.051 Torr; Sealed tube;

With hydrogenchloride; In water; acetonitrile; at 0 ℃; for 0.25h;

DOI:10.1021/acs.orglett.6b01598

Reference yield: 90.0%

2-Picolinic acid (98-98-6) + methanol (67-56-1) → methyl 2-pyridinecarboxylate hydrochloride + 2-picolinic acid hydrochloride (636-80-6)

Guidance literature:

With thionyl chloride; at 0 - 20 ℃; for 7h; Reflux;

Reference yield:

2-Picolinic acid (98-98-6) → 2-picolinic acid hydrochloride (636-80-6)

Guidance literature:

With antimony(III) chloride; In water; Heating;

DOI:10.1107/S0108270195000175

upstream raw materials:

2-Picolinic acid

pyridine-2-carbaldehyde

methanol

Downstream raw materials:

octyl 2-pyridinecarboxylate

butyl pyridine-2-carboxylate

Picolinsaeure-hexylester

chromium(III) picolinate hydrate

Refernces

• 1、 Smith, Graham,Byriel, Karl A.,Kennard, Colin H. L.. "2-Carboxypyridinium Chloride Monohydrate". . p. 1425 - 1427. Retrieved 1995.
• 2、 -. "Method for preparing methyl 4-chloropicolinate". Paragraph 0014. . Retrieved 2017/01/19.