{[17-oxoestra-1,3,5(10)-trien-3-yl]oxy}acetic acid

Base Information

Chemical Name:{[17-oxoestra-1,3,5(10)-trien-3-yl]oxy}acetic acid
CAS No.:1428-66-6
Molecular Formula:C20H24 O4
Molecular Weight:328.408
Hs Code.:

Synonyms:3-O-(Carboxymethyl)estrone;Estra-1,3,5-(10)-trien-17-one-3-oxyacetic acid; Estrone 3-carboxymethyl ether;NSC 14491; NSC 86467; RS 986

Suppliers and Price of {[17-oxoestra-1,3,5(10)-trien-3-yl]oxy}acetic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
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price

Total 8 raw suppliers

Chemical Property of {[17-oxoestra-1,3,5(10)-trien-3-yl]oxy}acetic acid

Chemical Property:

Vapor Pressure:1.77E-11mmHg at 25°C
Boiling Point:516.1°Cat760mmHg
Flash Point:184.4°C
Density:1.221g/cm³

Purity/Quality:: 99% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of {[17-oxoestra-1,3,5(10)-trien-3-yl]oxy}acetic acid

There total 9 articles about {[17-oxoestra-1,3,5(10)-trien-3-yl]oxy}acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

: 41164-32-3
3-ethyloxycarbonylmethylenoxyestrone

: 1428-66-6
2-(((8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)oxy)acetic acid

Guidance literature:: DOI:10.1016/S0039-128X(01)00112-X

Reference yield:

: 53-16-7
Estrone

: 105-36-2
ethyl bromoacetate

: 1428-66-6
2-(((8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)oxy)acetic acid

Guidance literature:: Estrone; ethyl bromoacetate; With potassium carbonate; In acetone; for 6h; Heating / reflux;

With sodium hydroxide; In 1,4-dioxane; water; at 20 ℃;

With hydrogenchloride; In 1,4-dioxane; water;

Reference yield:

: 53-16-7
Estrone

: 1428-66-6
2-(((8R,9S,13S,14S)-13-methyl-17-oxo-7,8,9,11,12,13,14,15,16,17-decahydro-6H-cyclopenta[a]phenanthren-3-yl)oxy)acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium ethoxide / ethanol; tetrahydrofuran / 0.5 h

1.2: 90 percent / ethanol; tetrahydrofuran / 16 h / 56 °C

2.1: 96 percent / aq. NaOH / ethanol / 2.5 h / 20 °C

With sodium hydroxide; sodium ethanolate; In tetrahydrofuran; ethanol;
DOI:10.1021/jm070242a