(Z)-ethyl 2-benzoyl-3-(4-Methoxyphenyl)acrylate

Base Information

• Chemical Name: (Z)-ethyl 2-benzoyl-3-(4-Methoxyphenyl)acrylate
• CAS No.: 148345-21-5
• Molecular Formula: C19H18O4
• Molecular Weight: 310.35
• Mol file: 148345-21-5.mol

Synonyms:(Z)-2-Benzoyl-3-(4-methoxy-phenyl)-acrylic acid ethyl ester;ethyl (Z)-3-(4-methoxyphenyl)-2-benzoylpropenoate;ethyl 2-benzoyl-3-(4-methoxyphenyl)acrylate;

Chemical Property of (Z)-ethyl 2-benzoyl-3-(4-Methoxyphenyl)acrylate

Chemical Property:

• Melting Point: 73 - 77 °C (benzene)
• PSA: 52.60000
• LogP: 3.52460

Purity/Quality:

97-99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (Z)-ethyl 2-benzoyl-3-(4-Methoxyphenyl)acrylate

There total 8 articles about (Z)-ethyl 2-benzoyl-3-(4-Methoxyphenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl 3-oxo-3-phenylpropionate (94-02-0) + 4-methoxy-benzaldehyde (123-11-5) → (Z)-ethyl 2-benzoyl-3-(4'-methoxyphenyl)-2-propenoate (148345-21-5)

Guidance literature:

With piperidine; acetic acid; In benzene; at 100 ℃;

DOI:10.1002/ejoc.200700156

Reference yield: 72.0%

(Z)-ethyl 3-acetyloxy-3-phenyl-2-propenoate (64967-44-8) + 4-methoxy-benzaldehyde (123-11-5) → (Z)-ethyl 2-benzoyl-3-(4'-methoxyphenyl)-2-propenoate (148345-21-5)

Guidance literature:

With Porcine Pancreas Lipase; In water; tert-butyl alcohol; Enzymatic reaction;

DOI:10.1002/chem.201901491

Reference yield: 39.0%

4-ethoxycarbonyl-3-(4'-methoxyphenyl)-2-methyl-5-phenyl-4-isoxazoline (148345-16-8) → (E)-ethyl 2-benzoyl-3-(4'-methoxyphenyl)-2-propenoate (148345-35-1) + (Z)-ethyl 2-benzoyl-3-(4'-methoxyphenyl)-2-propenoate (148345-21-5) + ethyl 2-benzoyl-3-dimethylamino-3-(4'-methoxyphenyl)-2-propenoate

Guidance literature:

With methyl iodide; Ambient temperature;

DOI:10.3987/COM-92-6223

upstream raw materials:

4-ethoxycarbonyl-3-(4'-methoxyphenyl)-2-methyl-5-phenyl-4-isoxazoline

methyl iodide

ethyl 3-oxo-3-phenylpropionate

4-methoxy-benzaldehyde

Downstream raw materials:

Sodium; (4R,5S,6R)-3-cyano-5-ethoxycarbonyl-6-hydroxy-4-(4-methoxy-phenyl)-6-phenyl-1,4,5,6-tetrahydro-pyridine-2-thiolate

2-Amino-4-(4-methoxy-phenyl)-6-phenyl-1,4-dihydro-pyrimidine-5-carboxylic acid ethyl ester

C₄₄H₃₄N₄O₆S₂

5-Cyano-4-(4-methoxy-phenyl)-2-phenyl-6-thioxo-1,4,5,6-tetrahydro-pyridine-3-carboxylic acid ethyl ester