Benzenepropanenitrile, b-[(trimethylsilyl)oxy]-

Base Information

• Chemical Name: Benzenepropanenitrile, b-[(trimethylsilyl)oxy]-
• CAS No.: 14904-40-6
• Molecular Formula: C12H17NOSi
• Molecular Weight: 219.359
• Mol file: 14904-40-6.mol

Synonyms:

Chemical Property of Benzenepropanenitrile, b-[(trimethylsilyl)oxy]-

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Benzenepropanenitrile, b-[(trimethylsilyl)oxy]-

There total 12 articles about Benzenepropanenitrile, b-[(trimethylsilyl)oxy]- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

chloro-trimethyl-silane (75-77-4) + benzaldehyde (100-52-7) + cyanomethyl bromide (590-17-0) → 3-phenyl-3-<(trimethylsilyl)oxy>propanenitrile (14904-40-6)

Guidance literature:

With zinc; In tetrahydrofuran; for 1h;

DOI:10.1016/0040-4039(90)80109-Y

Reference yield: 70.2%

2-trimethylsilylacetonitrile (18293-53-3) + benzaldehyde (100-52-7) → 3-phenyl-3-<(trimethylsilyl)oxy>propanenitrile (14904-40-6)

Guidance literature:

With potassium fluoride; In neat (no solvent); for 1.5h; Irradiation;

Reference yield: 70.0%

styrene oxide (96-09-3) + trimethylsilyl cyanide (7677-24-9) → 3-phenyl-3-<(trimethylsilyl)oxy>propanenitrile (14904-40-6)

Guidance literature:

With MgAlCO₃-HT; In n-heptane; for 0.5h; Ambient temperature;

DOI:10.1080/00397919508011830

upstream raw materials:

chloro-trimethyl-silane

Sodium acetonitrile

benzaldehyde

2-trimethylsilylacetonitrile

Downstream raw materials:

cinnamonitrile

3-hydroxy-3-phenylpropanenitrile

Refernces

• 1、 Yamasaki,Kanai,Shibasaki. "Novel multiaction of Zr catalyst: One-pot synthesis of β-cyanohydrins from olefins [14]". . p. 1256 - 1257. Retrieved 2007/10/03.
• 2、 Jolivet, Sandrine,Abdallah-El Ayoubi, Sahar,Mathe, Daniel,Texier-Boullet, Francoise,Hamelin, Jack. "Improved Synthesis of β-Trimethylsilyloxy Nitriles in a Solvent-free Reaction under Classical Heating or Microwave Activation". . p. 300 - 301. Retrieved 2007/10/03.