2,2-Dichloro-5-(2-phenylethyl)-4-(trimethylsilyl)furan-3(2H)-one

Base Information

Chemical Name:2,2-Dichloro-5-(2-phenylethyl)-4-(trimethylsilyl)furan-3(2H)-one
CAS No.:166387-67-3
Molecular Formula:C15H18Cl2O2Si
Molecular Weight:329.29400
Hs Code.:
DSSTox Substance ID:DTXSID50435469
Nikkaji Number:J627.078F
Wikidata:Q82250434
Mol file:166387-67-3.mol

Synonyms:166387-67-3;DPTF;DTXSID50435469;2,2-Dichloro-5-(2-phenylethyl)-4-(trimethylsilyl)furan-3(2H)-one;2,2-Dichloro-4-trimethylsilyl-5-phenethyl-3(2H)-furanone

Suppliers and Price of 2,2-Dichloro-5-(2-phenylethyl)-4-(trimethylsilyl)furan-3(2H)-one

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Total 0 raw suppliers

Chemical Property of 2,2-Dichloro-5-(2-phenylethyl)-4-(trimethylsilyl)furan-3(2H)-one

Chemical Property:

PSA：26.30000
LogP:4.48140
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:2
Rotatable Bond Count:4
Exact Mass:328.0453117
Heavy Atom Count:20
Complexity:418

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C[Si](C)(C)C1=C(OC(C1=O)(Cl)Cl)CCC2=CC=CC=C2

Technology Process of 2,2-Dichloro-5-(2-phenylethyl)-4-(trimethylsilyl)furan-3(2H)-one

There total 1 articles about 2,2-Dichloro-5-(2-phenylethyl)-4-(trimethylsilyl)furan-3(2H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 79-37-8
oxalyl dichloride

: 40277-01-8
1-(trimethylsilyl)-4-phenyl-1-butyne

: 166387-67-3
2,2-Dichloro-5-(2-phenylethyl)-4-(trimethylsilyl)-3(2H)-furanone

Guidance literature:: With aluminium trichloride; In dichloromethane; at -78 ℃; for 3h;
DOI:10.1021/jo00104a058

Reference yield: 98.0%

: 67-56-1
methanol

: 166387-67-3
2,2-Dichloro-5-(2-phenylethyl)-4-(trimethylsilyl)-3(2H)-furanone

: 166387-72-0
Methyl 2,2-dimethoxy-4-oxo-6-phenylhexanoate

Guidance literature:: for 14h; Ambient temperature;
DOI:10.1021/jo00104a058

Reference yield:

: 166387-67-3
2,2-Dichloro-5-(2-phenylethyl)-4-(trimethylsilyl)-3(2H)-furanone

: (2S*,4R*)-2-Hydroxy-6-phenyl-4-hexanolide

Guidance literature:: Multi-step reaction with 4 steps

1: 98 percent / 14 h / Ambient temperature

2: 98 percent / NaBH₄ / methanol / 24 h / -20 °C

3: 87 percent / TsOH*H₂O / acetone / 8.5 h / 80 °C

4: 81 percent / H₂ / 5percent Pd/C / ethyl acetate / 1 h / 760 Torr / Ambient temperature

With sodium tetrahydroborate; hydrogen; toluene-4-sulfonic acid; palladium on activated charcoal; In methanol; ethyl acetate; acetone;
DOI:10.1021/jo00104a058