2-(4-Methoxyphenyl)-4-phenylthiazole

Base Information

• Chemical Name: 2-(4-Methoxyphenyl)-4-phenylthiazole
• CAS No.: 2227-71-6
• Molecular Formula: C16H13NOS
• Molecular Weight: 267.351
• DSSTox Substance ID: DTXSID10429283
• Nikkaji Number: J1.050.648D
• Wikidata: Q82242282
• Mol file: 2227-71-6.mol

Synonyms:2-(4-Methoxyphenyl)-4-phenylthiazole;2227-71-6;SCHEMBL6693465;DTXSID10429283;VIYMRRDTACPLHE-UHFFFAOYSA-N;AKOS034401406;Z48856063

Chemical Property of 2-(4-Methoxyphenyl)-4-phenylthiazole

Chemical Property:

• XLogP3: 4.2
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 267.07178521
• Heavy Atom Count: 19
• Complexity: 272

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: COC1=CC=C(C=C1)C2=NC(=CS2)C3=CC=CC=C3

Technology Process of 2-(4-Methoxyphenyl)-4-phenylthiazole

There total 16 articles about 2-(4-Methoxyphenyl)-4-phenylthiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

2-(4-methoxyphenyl)-1,3-thiazole (27088-84-2) + phenylboronic acid (98-80-6) → 2-(4′-methoxyphenyl)-4-phenylthiazole (2227-71-6)

Guidance literature:

With lithium tetrafluoroborate; 1,10-Phenanthroline; 2,2,6,6-Tetramethyl-1-piperidinyloxy free radical; palladium diacetate; In N,N-dimethyl acetamide; at 100 ℃; for 24h; regioselective reaction;

DOI:10.1039/c3sc52199k

Reference yield: 91.0%

p-methoxythiobenzamide (2362-64-3) + 1-phenyl-2-(p-tolylsulfonyloxy)ethanone (7257-94-5) → 2-(4′-methoxyphenyl)-4-phenylthiazole (2227-71-6)

Guidance literature:

With montmorillonite K-10; at 130 ℃; for 0.0666667h;

DOI:10.1039/a807563h

Reference yield: 89.5%

p-methoxythiobenzamide (2362-64-3) + α-bromoacetophenone (70-11-1) → 2-(4′-methoxyphenyl)-4-phenylthiazole (2227-71-6)

Guidance literature:

In ethanol;

upstream raw materials:

p-methoxythiobenzamide

α-bromoacetophenone

4-Methoxy-dithiobenzoic acid 2-[(E)-hydroxyimino]-2-phenyl-ethyl ester

α-(4-methoxythiobenzoylthio)-acetophenone

Downstream raw materials:

3-(4-methoxyphenyl)-5-phenylisothiazole

4-(4′-methoxyphenyl)-2-phenylthiazole

1,3-bis-{4-[2-(4-methoxy-phenyl)-thiazol-4-yl]-phenyl}-thiourea

4-[2-(4-methoxy-phenyl)-thiazol-4-yl]-aniline