N-(2-Chloro-4-methoxyphenyl)acetamide

Base Information

• Chemical Name: N-(2-Chloro-4-methoxyphenyl)acetamide
• CAS No.: 31601-42-0
• Molecular Formula: C9H10ClNO2
• Molecular Weight: 199.637
• NSC Number: 631647
• DSSTox Substance ID: DTXSID301285571
• Nikkaji Number: J315.141G
• Mol file: 31601-42-0.mol

Synonyms:N-(2-Chloro-4-methoxyphenyl)acetamide;NSC631647;31601-42-0;SCHEMBL7035785;DTXSID301285571;NSC-631647;N-(2-chloro-4-methoxy-phenyl)acetamide

Chemical Property of N-(2-Chloro-4-methoxyphenyl)acetamide

Chemical Property:

• Vapor Pressure: 1.69E-05mmHg at 25°C
• XLogP3: 1.5
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 2
• Exact Mass: 199.0400063
• Heavy Atom Count: 13
• Complexity: 187

Purity/Quality:

95% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(=O)NC1=C(C=C(C=C1)OC)Cl

Technology Process of N-(2-Chloro-4-methoxyphenyl)acetamide

There total 11 articles about N-(2-Chloro-4-methoxyphenyl)acetamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

4-methoxyacetanilide (51-66-1) → N-(2-chloro-4-methoxyphenyl)acetamide (31601-42-0)

Guidance literature:

With N-chloro-succinimide; In acetonitrile; for 2h; regioselective reaction; Irradiation;

DOI:10.1002/ejoc.201801097

Reference yield: 84.0%

4-acetamido-3-chlorophenol (56074-07-8) → N-(2-chloro-4-methoxyphenyl)acetamide (31601-42-0)

Guidance literature:

With sodium carbonate; methyl iodide; In acetonitrile; for 48h; Heating / reflux;

Reference yield: 63.0%

methanol (67-56-1) + N-(2-chlorophenyl)acetamide (533-17-5) → N-(2-chloro-4-methoxyphenyl)acetamide (31601-42-0)

Guidance literature:

With boron trifluoride diethyl etherate; bis-[(trifluoroacetoxy)iodo]benzene; at 20 ℃; for 2h; regioselective reaction;

DOI:10.1039/c0ob00749h

upstream raw materials:

2-chloro-4-methoxyaniline

4-methoxyacetanilide

para-methoxynitrobenzene

N,N'-bis(4-methoxyphenyl)urea

Downstream raw materials:

2-chloro-4-methoxyaniline