1-(Phenylsulfonyl)aziridine

Base Information

• Chemical Name: 1-(Phenylsulfonyl)aziridine
• CAS No.: 10302-15-5
• Molecular Formula: C8H9 N O2 S
• Molecular Weight: 183.231
• European Community (EC) Number: 233-676-2
• DSSTox Substance ID: DTXSID8065030
• Nikkaji Number: J236.755F
• Wikidata: Q81991929
• Mol file: 10302-15-5.mol

Synonyms:1-(PHENYLSULFONYL)AZIRIDINE;1-(benzenesulfonyl)aziridine;10302-15-5;1-(Phenylsulphonyl)aziridine;Aziridine, 1-(phenylsulfonyl)-;N-Benzenesulfonylaziridine;HSDB 6153;EINECS 233-676-2;AI3-50705;phenylsulfonylaziridine;SCHEMBL735657;DTXSID8065030;AKOS000278673;EN300-1456576

Chemical Property of 1-(Phenylsulfonyl)aziridine

Chemical Property:

• Vapor Pressure: 0.000551mmHg at 25°C
• Boiling Point: 311.8°Cat760mmHg
• PKA: -6.68±0.20(Predicted)
• Flash Point: 142.4°C
• Density: 1.392g/cm³
• XLogP3: 0.8
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 2
• Exact Mass: 183.03539970
• Heavy Atom Count: 12
• Complexity: 245

Purity/Quality:

98%,99%, ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Chemical Classes: Nitrogen Compounds -> Other Aromatics (Nitrogen)
• Canonical SMILES: C1CN1S(=O)(=O)C2=CC=CC=C2

Technology Process of 1-(Phenylsulfonyl)aziridine

There total 6 articles about 1-(Phenylsulfonyl)aziridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

ethanolamine (141-43-5) + benzenesulfonyl chloride (98-09-9) → N-(phenylsulfonyl)aziridine (10302-15-5)

Guidance literature:

With pyridine; at -15 - 0 ℃; Inert atmosphere;

DOI:10.1039/c8cc01062e

Reference yield:

N-(2-bromo-ethyl)-benzenesulfonamide (6453-88-9) → N-(phenylsulfonyl)aziridine (10302-15-5)

Guidance literature:

In 1-methyl-pyrrolidin-2-one; for 1h; Alkaline conditions;

DOI:10.1039/c7ob02915b

Reference yield:

N-(2-chloro-ethyl)-benzenesulfonamide (6453-86-7) → N-(phenylsulfonyl)aziridine (10302-15-5)

Guidance literature:

With sodium hydroxide;

upstream raw materials:

ethyleneimine

benzenesulfonyl chloride

N-(2-chloro-ethyl)-benzenesulfonamide

N-(2-bromo-ethyl)-benzenesulfonamide

Downstream raw materials:

tetrakis-N-(2-benzenesulfonylamino-ethyl)-ethylenediamine

N-<2-(2-Thienyl)ethyl>benzolsulfonamid

Refernces

• 1、 Paoletti,P. et al.. "-". . p. 243 - 265. Retrieved 1971.
• 2、 Qian, Guangyin,Bai, Miao,Gao, Shijun,Chen, Han,Zhou, Siwei,Cheng, Hong-Gang,Yan, Wei,Zhou, Qianghui. "Modular One-Step Three-Component Synthesis of Tetrahydroisoquinolines Using a Catellani Strategy". supporting information. p. 10980 - 10984. Retrieved 2018/07/30.