Technology Process of 1,3-Propanedione, 1-[1,1'-biphenyl]-4-yl-3-phenyl-
There total 7 articles about 1,3-Propanedione, 1-[1,1'-biphenyl]-4-yl-3-phenyl- which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
aluminum (III) chloride;
In
dichloromethane;
at 0 ℃;
for 12h;
Inert atmosphere;
- Guidance literature:
-
biphenyl-4-acetaldehyde;
In
toluene;
at 0 ℃;
for 0.5h;
Inert atmosphere;
With
lithium hexamethyldisilazane;
In
tetrahydrofuran; toluene;
at 0 ℃;
for 0.5h;
Inert atmosphere;
benzoyl chloride;
In
tetrahydrofuran; toluene;
for 0.0333333h;
Inert atmosphere;
DOI:10.1021/acs.joc.0c02366
- Guidance literature:
-
methyl 2-([1,1'-biphenyl]-4-yl)-2-oxoacetate; α-bromoacetophenone;
With
potassium carbonate;
In
1-methyl-pyrrolidin-2-one; methanol;
at 20 ℃;
for 4h;
Schlenk technique;
Inert atmosphere;
With
potassium hydroxide;
In
1-methyl-pyrrolidin-2-one; methanol; water;
at 20 ℃;
for 2h;
regioselective reaction;
Schlenk technique;
Inert atmosphere;
DOI:10.1021/acs.joc.6b02575
