Phosphoric acid, diphenyl 1-phenylethenyl ester

Base Information

• Chemical Name: Phosphoric acid, diphenyl 1-phenylethenyl ester
• CAS No.: 50523-12-1
• Molecular Formula: C20H17O4P
• Molecular Weight: 352.326
• Mol file: 50523-12-1.mol

Synonyms:

Chemical Property of Phosphoric acid, diphenyl 1-phenylethenyl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Phosphoric acid, diphenyl 1-phenylethenyl ester

There total 4 articles about Phosphoric acid, diphenyl 1-phenylethenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

acetophenone (98-86-2) + chlorophosphoric acid diphenyl ester (2524-64-3) → 1-phenyl-eth-1-en-1-yl diphenyl phosphate (50523-12-1)

Guidance literature:

acetophenone; With lithium hexamethyldisilazane; In tetrahydrofuran; at -78 ℃; for 0.5h;

chlorophosphoric acid diphenyl ester; In tetrahydrofuran; at -78 - 20 ℃; Further stages.;

DOI:10.1002/anie.200600442

Reference yield: 88.0%

diphenyl hydrogen phosphate (838-85-7) + phenylacetylene (536-74-3) → 1-phenyl-eth-1-en-1-yl diphenyl phosphate (50523-12-1)

Guidance literature:

With silver(I) hexafluorophosphate; (triphenylphosphine)gold(I) chloride; In toluene; at 60 ℃; for 12h; regioselective reaction; Inert atmosphere;

DOI:10.1002/anie.201001799

Reference yield:

lithium 1-phenylethenolate (1052762-47-6) + chlorophosphoric acid diphenyl ester (2524-64-3) → 1-phenyl-eth-1-en-1-yl diphenyl phosphate (50523-12-1)

Guidance literature:

DOI:10.1016/0040-4039(80)80120-1

upstream raw materials:

diphenyl methyl phosphite

1-chloroacetophenone

acetophenone

chlorophosphoric acid diphenyl ester

Downstream raw materials:

1-phenyl-1-p-tolyl-ethylene

2,4-diphenylbut-1-en-3-yne

1-ethylstyrene

isopropenylbenzene

Refernces

• 1、 Kotek, Vladislav,Polák, Peter,Dvo?áková, Hana,Tobrman, Tomá?. "Aluminum Chloride Promoted Cross-Coupling of Trisubstituted Enol Phosphates with Organozinc Reagents En Route to the Stereoselective Synthesis of Tamoxifen and Its Analogues". supporting information. p. 5037 - 5044. Retrieved 2016/10/26.
• 2、 Lee, Phil Ho,Kim, Sundae,Park, Aeri,Chary, Bathoju Chandra,Kim, Sunggak. "Gold(I)-catalyzed addition of diphenyl phosphate to alkynes: Isomerization of kinetic enol phosphates to the thermodynamically favored isomers". supporting information; experimental part. p. 6806 - 6809. Retrieved 2010/12/19.