8-Ethoxy-1,4-dioxaspiro[4.5]decane

Base Information

• Chemical Name: 8-Ethoxy-1,4-dioxaspiro[4.5]decane
• CAS No.: 55103-52-1
• Molecular Formula: C10H18O3
• Molecular Weight: 186.251
• Hs Code.: 2932999099
• Mol file: 55103-52-1.mol

Synonyms:4-ethoxycyclohexanone ethylene ketal;8-(ethyloxy)-1,4-dioxaspiro[4.5]decane;1,4-Dioxaspiro[4.5]decane,8-ethoxy;

Chemical Property of 8-Ethoxy-1,4-dioxaspiro[4.5]decane

Chemical Property:

• PSA: 27.69000
• LogP: 1.70860

Purity/Quality:

8-Ethoxy-1,4-dioxaspiro[4.5]decane 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 8-Ethoxy-1,4-dioxaspiro[4.5]decane

There total 5 articles about 8-Ethoxy-1,4-dioxaspiro[4.5]decane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

4,4-ethylenedioxycyclohexan-1-ol (22428-87-1) + ethyl iodide (75-03-6) → 4-ethoxycyclohexanone ethylene ketal (55103-52-1)

Guidance literature:

With potassium hydroxide; In dimethyl sulfoxide; Ambient temperature;

DOI:10.1039/a605638e

Reference yield:

ethyl iodide (75-03-6) → 4-ethoxycyclohexanone ethylene ketal (55103-52-1)

Guidance literature:

4,4-ethylenedioxycyclohexan-1-ol; With sodium hydride; In 1-methyl-pyrrolidin-2-one; at 10 ℃; for 1h;

ethyl iodide; In 1-methyl-pyrrolidin-2-one; at 20 ℃; for 21.5h;

Reference yield:

cyclohexanedione monoethylene ketal (4746-97-8) → 4-ethoxycyclohexanone ethylene ketal (55103-52-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 98 percent / sodium borohydride / methanol / 1 h

2: 0.81 g / sodium hydride

With sodium tetrahydroborate; sodium hydride; In methanol;

DOI:10.1021/jo061349t

upstream raw materials:

4,4-ethylenedioxycyclohexan-1-ol

ethyl iodide

ethyl bromide

cyclohexanedione monoethylene ketal

Downstream raw materials:

4-Ethoxycyclohexanon-2,2,6,6-d⁽⁴⁾

ethyl-cyclohex-3-enyl ether

4-ethoxycyclohexan-1-ol

C₈H₁₅⁽²⁾HO₂

Refernces

• 1、 -. "AMIDE COMPOUNDS AND METHOD FOR MAKING AND USING". Paragraph 0653-0655. . Retrieved 2018/05/03.
• 2、 -. "1- (1-CYCLOHEXYL-4-PIPERIDINYL) -1, 3-DIHYDRO-2H-BENZIMIDAZOL-2-ONE DERIVATIVES WHICH HAVE ACTIVITY ON THE M1 RECEPTOR AND THEIR USE IN MEDICINE". Page/Page column 56. . Retrieved 2008/12/04.