ETHYL 2-[(4-NITROBENZOYL)AMINO]ACETATE

Base Information

• Chemical Name: ETHYL 2-[(4-NITROBENZOYL)AMINO]ACETATE
• CAS No.: 7512-77-8
• Molecular Formula: C11H12 N2 O5
• Molecular Weight: 252.227
• Mol file: 7512-77-8.mol

Synonyms:Hippuric acid,p-nitro-, ethyl ester (6CI); Ethyl 4-nitrohippurate; Ethyl p-nitrohippurate;NSC 402848

Chemical Property of ETHYL 2-[(4-NITROBENZOYL)AMINO]ACETATE

Chemical Property:

• Vapor Pressure: 1.97E-08mmHg at 25°C
• Melting Point: 147-149°C
• Boiling Point: 454°Cat760mmHg
• Flash Point: 228.4°C
• Density: 1.295g/cm³

Purity/Quality:

97% ^*data from raw suppliers

Ethyl 2-[(4-nitrobenzoyl)amino]acetate >95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of ETHYL 2-[(4-NITROBENZOYL)AMINO]ACETATE

There total 16 articles about ETHYL 2-[(4-NITROBENZOYL)AMINO]ACETATE which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

ethyl N-diphenylmethylene glycine (69555-14-2) + 4-nitro-benzoyl chloride (122-04-3) → benzophenone (119-61-9) + ethyl 2-(4-nitrobenzamido)acetate (7512-77-8)

Guidance literature:

With sodium hydride; In tetrahydrofuran; 1.) 0 deg C, 0.5 h; 2.) r.t., 12 h;

DOI:10.1016/S0040-4039(01)80783-8

Reference yield: 76.0%

Ethyl isocyanoacetate (2999-46-4) + 4-nitrobenzenediazonium tetrafluoroborate (456-27-9) → ethyl 2-(4-nitrobenzamido)acetate (7512-77-8)

Guidance literature:

With water; sodium acetate; In acetonitrile; at 0 ℃; for 1.16667h; Inert atmosphere;

DOI:10.1002/anie.201302659

Reference yield: 74.0%

glycine ethyl ester hydrochloride (623-33-6) + N-amino-(4-nitrophenyl)carboxamide (636-97-5) → ethyl 2-(4-nitrobenzamido)acetate (7512-77-8)

Guidance literature:

With thallium(III) nitrate trihydrate; triethylamine; In acetonitrile; Ambient temperature; 1.) 0 deg C, 10 min, 2.) r.t., 2 h;

DOI:10.1021/jo00110a059

upstream raw materials:

ethyl N-diphenylmethylene glycine

4-nitro-benzoyl chloride

4-Nitro-benzoic acid 4,5-dimethyl-[1,2,3]triazol-1-yl ester

GlyOEt*HCl

Downstream raw materials:

4-nitrohippuric acid

N-(4-amino-benzoyl)-glycine ethyl ester

4-nitrobenzoyl glycine amide

N-(4-nitro-benzoyl)-glycine hydrazide