6-broMo-3-(4-broMophenyl)-3,4-dihydroquinazoline

Base Information

• Chemical Name: 6-broMo-3-(4-broMophenyl)-3,4-dihydroquinazoline
• CAS No.: 65331-45-5
• Molecular Formula: C14H10Br2N2
• Molecular Weight: 366.055
• Hs Code.: 2933990090
• Mol file: 65331-45-5.mol

Synonyms:6-bromo-3-(4-bromophenyl)-3,4-dihydroquinazoline;

Chemical Property of 6-broMo-3-(4-broMophenyl)-3,4-dihydroquinazoline

Chemical Property:

• PSA: 15.60000
• LogP: 4.39220

Purity/Quality:

6-bromo-3-(4-bromophenyl)-3,4-dihydroquinazoline 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 6-broMo-3-(4-broMophenyl)-3,4-dihydroquinazoline

There total 7 articles about 6-broMo-3-(4-broMophenyl)-3,4-dihydroquinazoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-methyl-6-bromo-3-(4-bromophenyl)-1,4-dihydroquinazolin-3-ium tetrafluoroborate → 6-bromo-3-(4-bromophenyl)-3,4-dihydroquinazoline (65331-45-5)

Guidance literature:

With sodium hydroxide; In ethanol; at 20 ℃; for 12h;

DOI:10.1016/j.tet.2010.03.057

Reference yield: 78.0%

N-(4-tert-butylbenzyl)-4-bromoaniline → 4-tert-Butylbenzaldehyde (939-97-9) + 6-bromo-3-(4-bromophenyl)-3,4-dihydroquinazoline (65331-45-5) + 4-chloro-aniline (106-47-8)

Guidance literature:

N-(4-tert-butylbenzyl)-4-bromoaniline; With toluene-4-sulfonic acid; dimethyl sulfoxide; at 125 ℃; for 49h; Green chemistry;

With hydrogenchloride; In water; at 20 ℃; for 1h; Time; Green chemistry;

DOI:10.1246/cl.190854

Reference yield: 57.0%

1,3-DIOXOLANE (646-06-0) + 4-bromo-aniline (106-40-1) → 6-bromo-3-(4-bromophenyl)-3,4-dihydroquinazoline (65331-45-5)

Guidance literature:

With trifluoroacetic acid; In benzene; at 80 - 85 ℃; for 1.5h;

DOI:10.1134/S1070363216070392

upstream raw materials:

formaldehyd

formic acid

4-bromo-aniline

hydrogenchloride

Downstream raw materials:

3-phenyl-1,2,3,4-tetrahydroquinazoline