4-Phenyl-6-(propan-2-yl)-3,6-dihydro-2H-pyran

Base Information

• Chemical Name: 4-Phenyl-6-(propan-2-yl)-3,6-dihydro-2H-pyran
• CAS No.: 65646-58-4
• Molecular Formula: C14H18O
• Molecular Weight: 202.296
• DSSTox Substance ID: DTXSID40495476
• Mol file: 65646-58-4.mol

Synonyms:65646-58-4;4-Phenyl-6-(propan-2-yl)-3,6-dihydro-2H-pyran;DTXSID40495476

Chemical Property of 4-Phenyl-6-(propan-2-yl)-3,6-dihydro-2H-pyran

Chemical Property:

• XLogP3: 3.3
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 1
• Rotatable Bond Count: 2
• Exact Mass: 202.135765193
• Heavy Atom Count: 15
• Complexity: 224

Purity/Quality:

85.0-99.8% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)C1C=C(CCO1)C2=CC=CC=C2

Technology Process of 4-Phenyl-6-(propan-2-yl)-3,6-dihydro-2H-pyran

There total 6 articles about 4-Phenyl-6-(propan-2-yl)-3,6-dihydro-2H-pyran which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 55.0%

4-methyl-4-phenyl-1,3-dioxane (1200-73-3) + isobutyraldehyde (78-84-2) → 4-phenyl-5,6-dihydro-2H-pyran (3174-81-0) + 2-Isopropyl-4-phenyl-3,6-dihydro-2H-pyrane (65646-56-2) + 2-Isopropyl-4-phenyl-5,6-dihydro-2H-pyrane (65646-58-4)

Guidance literature:

With sulfuric acid; In toluene; at 110 ℃; for 2.5h;

Reference yield: 55.0%

2-isopropyl-4-methyl-4-phenyl-1,3-dioxane (64820-72-0) → 2-Isopropyl-4-phenyl-3,6-dihydro-2H-pyrane (65646-56-2) + 2-Isopropyl-4-phenyl-5,6-dihydro-2H-pyrane (65646-58-4)

Guidance literature:

With sulfuric acid; at 110 ℃; for 2.5h; Product distribution; other acid (cation-exchange resin KU-2, p-TSA);

Reference yield: 45.0%

2-methyl-1,2-epoxypropane (558-30-5) + 3-Butyn-1-ol (927-74-2) + benzene (71-43-2,26181-88-4,54682-86-9,13967-78-7,174973-66-1) → 2-Isopropyl-4-phenyl-5,6-dihydro-2H-pyrane (65646-58-4)

Guidance literature:

With boron trifluoride diethyl etherate; at 20 ℃; for 5h; Inert atmosphere;

DOI:10.1055/s-0029-1219779

upstream raw materials:

2-isopropyl-4-methyl-4-phenyl-1,3-dioxane

4-methyl-4-phenyl-1,3-dioxane

isobutyraldehyde

formaldehyd