DODECYLMALONIC ACID

Base Information

• Chemical Name: DODECYLMALONIC ACID
• CAS No.: 4371-74-8
• Molecular Formula: C15H28O4
• Molecular Weight: 272.385
• Hs Code.: 2917190090
• Mol file: 4371-74-8.mol

Synonyms:1,1-Tridecanedicarboxylic acid;2-dodecyl propane dioic acid;Malonic acid,dodecyl;Propanedioic acid,dodecyl;Dodecyl-malonsaeure;dodecylmalonic acid;

Chemical Property of DODECYLMALONIC ACID

Chemical Property:

• Vapor Pressure: 1.68E-08mmHg at 25°C
• Boiling Point: 427.4°Cat760mmHg
• Flash Point: 226.4°C
• PSA: 74.60000
• Density: 1.024g/cm³
• LogP: 4.08280

Purity/Quality:

99% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of DODECYLMALONIC ACID

There total 7 articles about DODECYLMALONIC ACID which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

diethyl 2-dodecylmalonate (7252-87-1) → dodecylmalonic acid (4371-74-8)

Guidance literature:

diethyl 2-dodecylmalonate; With potassium hydroxide; In ethanol; water-d2;

With hydrogenchloride; In ethanol; water-d2; pH=1;

Reference yield: 50.0%

methanol (67-56-1) + methyl 2-trifluoromethyltetradecanoate (693244-98-3) → dodecylmalonic acid (4371-74-8) + dimethyl 2-dodecylmalonate (36986-30-8) + methyl dodecylmalonate (36986-31-9)

Guidance literature:

methanol; methyl 2-trifluoromethyltetradecanoate; With sodium hydroxide; In tetrahydrofuran; water; at 20 ℃;

With hydrogenchloride; In tetrahydrofuran; water;

DOI:10.1002/chem.201003176

Reference yield:

1-dodecylbromide (143-15-7) + diethyl malonate (105-53-3) → dodecylmalonic acid (4371-74-8)

Guidance literature:

With potassium hydroxide; water; sodium ethanolate; Multistep reaction;

DOI:10.1016/S0040-4039(01)90331-4

upstream raw materials:

diethyl 2-dodecylmalonate

1-dodecylbromide

diethyl malonate

Oxalyl bromide

Downstream raw materials:

14,15-octacosanedione

hexadecane-2,3-dione

1-tetracosene

Refernces

• 1、 Geneste, P.,Guida, A.,Reminiac, C.,Amblard, G.,Gavach, C.. "TRANSPORT DES CATIONS A TRAVERS DES MEMBRANES LIPIDIQUES BIMOLECULARES PAR DES NOUVEAUX MACROCYCLES DI ET TETRAESTERS POLYETHERES HYDROPHOBES". . p. 1397 - 1398. Retrieved 1981.
• 2、 Morgenroth, Agnieszka,Urusova, Elizaveta A.,Dinger, Cornelia,Al-Momani, Ehab,Kull, Thomas,Glatting, Gerhard,Frauendorf, Holm,Jahn, Olaf,Mottaghy, Felix M.,Reske, Sven N.,Zlatopolskiy, Boris D.. "New molecular markers for prostate tumor imaging: A study on 2-methylene substituted fatty acids as new AMACR inhibitors". supporting information; experimental part. p. 10144 - 10150. Retrieved 2011/10/09.